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Advisor(s)
Abstract(s)
The gut microbiota, recognised for its vital functions in host health, operates as an endocrine organ, exerting systemic effects beyond the gastrointestinal tract. This “virtual organ” produces
hormones that influence distal organs, including the brain. With its diverse microbial composition, the gut microbiota surpasses the biochemical complexity of traditional endocrine organs, generating
neurotransmitters like GABA, dopamine, and serotonin. Despite challenges in culturing gut bacteria,
advances in research methodologies have elucidated their role in behaviour, metabolism, appetite,
and insulin resistance. As microbial endocrinology continues to evolve, further exploration of the
intricate connections between hormones and the microbiome are anticipated, highlighting hormones’
pivotal role in the dynamic host–microbiota relationship.
Description
Keywords
Gut microbiota Endocrine organ Virtual organ Neurotransmitters Microbial endocrinology Intricate connections
Pedagogical Context
Citation
Pires, Lara; Gonzalez-Paramás, Ana Maria; Heleno, Sandrina A.; Calhelha, Ricardo C. (2024). Gut Microbiota as an Endocrine Organ: Unveiling Its Role in Human Physiology and Health. Applied Sciences. ISSN 2076-3417. 14:20, p. 1-30
Publisher
MDPI