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Advisor(s)
Abstract(s)
Being Cordyceps militaris (L.) Link recognized as a medicinal and edible mushroom,
this work intends to reveal new interesting bioactive molecules that could be isolated
from this species. Hydrophilic and lipophilic compounds were analysed by
chromatographic techniques coupled to different detectors. The methanolic extract of C.
militaris was tested for its antioxidant, antibacterial, antifungal and anti-proliferative
properties in different human tumor cell lines. Mannitol (2.01 g/100 g dw) and trehalose
(24.71 g/100 g) were the free sugars found in C. militaris. Polyunsaturated fatty acids
(68.87%) predominated over saturated fatty acids (23.40%) and δ-tocopherol was the
only isoform of vitamin E detected (55.86 μg/100 g). The organic acids found in this
mushroom were oxalic, citric and fumaric acids (0.33, 7.97 and 0.13 g/100g,
respectively). p-Hydroxybenzoic acid was the only phenolic acid quantified in this
species (0.02 mg/100 g); although cinnamic acid was also found (0.11 mg/100 g). The
methanolic extract of C. militaris proved to inhibit lipid peroxidation, have reducing
power and scavenge free radicals. This extract also revealed strong antibacterial and
antifungal properties. Finally, the C. militaris extract was able to inhibit the
proliferation of MCF-7 (breast), NCI-H460 (non-small lung), HCT-15 (colon) and
HeLa (cervical) human carcinoma cell lines.
Description
Keywords
Medicinal/edible mushroom Cordyceps militaris Chemical characterization Antioxidant potential Antimicrobial activity Anti-proliferative properties
Citation
Reis, Filipa S.; Barros, Lillian; Calhelha, Ricardo C.; Ciric, Ana; van Griensven, Leo J.L.D.; Sokovic, Marina; Ferreira, Isabel C.F.R. (2013). The methanolic extract of Cordyceps militaris (L.) Link fruiting body shows antioxidant, antibacterial, antifungal and anti human tumor cell lines properties. Food and Chemical Toxicology. ISSN 0278-6915. 62, p. 91–98
Publisher
Elsevier