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Exploring the bioactive potential of Artemisia annua L. hydroethanolic extracts obtained by microwave-assisted extraction

2022Documento de conferência Acesso aberto
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dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorAlves, Maria José
dc.contributor.authorBarros, Lillian
dc.contributor.authorPinho, Simão
dc.contributor.authorAyuso, Manuel
dc.date.accessioned2023-03-15T15:29:37Z
dc.date.available2023-03-15T15:29:37Z
dc.date.issued2022
dc.description.abstractArtemisia annua L. is known for producing artemisinin, a sesquiterpene lactone compound, which is applied to treat of malaria [1]. Its pharmacodynamic and pharmacokinetic characteristics, as well as its strong capacity for Plasmodium elimination, have raised many expectations for this new class of antimalarial drugs [2]. However, this plant has been also used in traditional Chinese medicine to treat of various diseases since ancient times. Recent studies have focused on its extensive biological activities, which makes this plant an excellent candidate to be used in clinical therapies. Thus, this work aimed to evaluate different bioactivities from a hydroethanolic extract of Artemisia annua. The plant extract in ethanol:water (80:20 v/v) was obtained by microwave-assisted extraction. The antioxidant activity was determined by thiobarbituric acid reactive substances (TBARS) assay, showing a potent activity with an IC50 of 10.3 ± 1.0 μg/mL. A. annua L. extract also exhibited antibacterial and antifungal properties, with concentrations ranging from 2.5 to 10 mg/mL. The ethanolic extract was very effective against the four tumor cell lines, presenting GI50 ranging from 21 to 61 μg/mL and excellent anti-inflammatory activity (38 μg/mL). However, it was also cytotoxic against the two normal cells tested (50 and 19 μg/mL). Concluding, despite the excellent biological activities exhibited by A. annua L. extract, it was also demonstrated to be cytotoxic against normal cells. Therefore, further studies are necessary to study how the cytotoxicity of this extract could be reduced without affecting its bioactive properties.pt_PT
dc.description.sponsorshipThe authors are thankful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES (PIDDAC) to CIMO (UIDB/00690/2020 and UIDP/00690/2020) and SusTEC (LA/P/0007/2020); national funding by FCT, P.I., through the institutional scientific employment program-contract for R.C.C., and L.B. contract. Manuel Ayuso is also grateful for his financial support through the PRIMA project LocalNutLeg (Section 1 2020 Agrofood Value Chain topic 1.3.1). The authors are also thankful to Project GreenHealth - Norte-01–0145-FEDER-000042.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMahjoub, Mohamed Amine; Calhelha, Ricardo C.; Alves, Maria José; Barros, Lillian; Pinho, Simão; Ayuso, Manuel (2022). Exploring the bioactive potential of Artemisia annua L. hydroethanolic extracts obtained by microwave-assisted extraction. In XXVI Encontro Galego-Portugues de Química: Book of Abstracts. Santiago de Compostela. ISBN 978-84-09-45895-0pt_PT
dc.identifier.isbn978-84-09-45895-0
dc.identifier.urihttp://hdl.handle.net/10198/27750
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherUniversidade de Santiago de Compostelapt_PT
dc.relationLA/P/0007/2020pt_PT
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectArtemisia annua L.pt_PT
dc.subjectResearch Subject Categories::TECHNOLOGY::Chemical engineering::Food technologypt_PT
dc.titleExploring the bioactive potential of Artemisia annua L. hydroethanolic extracts obtained by microwave-assisted extractionpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardNumberUIDB/00690/2020
oaire.awardNumberUIDP/00690/2020
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.citation.conferencePlaceSantiago de Compostelapt_PT
oaire.citation.endPage596pt_PT
oaire.citation.startPage596pt_PT
oaire.citation.titleXXVI Encontro Galego-Portugues de Química: Book of Abstractspt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCalhelha
person.familyNameAlves
person.familyNameBarros
person.familyNamePinho
person.familyNameAyuso
person.givenNameRicardo C.
person.givenNameMaria José
person.givenNameLillian
person.givenNameSimão
person.givenNameManuel
person.identifier469085
person.identifier810882
person.identifierABC-7764-2020
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person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0001-8506-4393
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-9211-857X
person.identifier.orcid0000-0002-1697-3857
person.identifier.ridJ-2172-2014
person.identifier.ridM-6624-2016
person.identifier.ridJ-3600-2013
person.identifier.ridD-4148-2013
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id16400584800
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id7003570175
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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