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Analytical metabolomics and applications in health, environmental and food science

2022Journal article Restricted access
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dc.contributor.authorFraga-Corral, Maria
dc.contributor.authorCarpena Rodríguez, María
dc.contributor.authorGarcia-Oliveira, Paula
dc.contributor.authorPereira, Antia Gonzalez
dc.contributor.authorPrieto Lage, Miguel A.
dc.contributor.authorSimal-Gandara, Jesus
dc.date.accessioned2024-01-24T12:27:21Z
dc.date.available2024-01-24T12:27:21Z
dc.date.issued2022
dc.description.abstractMetabolomics is a young field of knowledge that arises linked to other omics such as genomics, transcriptomics, and proteomics. This discipline seeks to understand the performance of metabolites, identifying, quantifying them, and thus understanding its mechanism of action. This new branch of omics science shows high potential, due to its noninvasive character and its close relation with phenotype. Several techniques have been developed to study the metabolome of biological samples, fundamentally nuclear magnetic resonance (NMR), mass spectrometry (MS) and vibrational spectrometry (VS) or a combination of several techniques. These techniques are focused to separate, detect, characterize, and quantify metabolites, as well as elucidate their structures and their function on the metabolic pathways they are involved. However, due to the complexity of the metabolome, in most cases it is necessary to apply several of these techniques to understand completely the whole scenery. This review is aimed to offer a summary of the current knowledge of these analytical techniques for metabolomics and their application to different fields as environmental, food or health sciences. Each technique shows different advantages and drawbacks depending on their technical characteristics and limitations, some factors, such as the aim of the study or the nature of the biological sample will condition the choice. Regarding their applications, NMR has been employed specially to identify new compounds and elucidate structures. The use of MS has gained popularity because of its versatility, easiness to be coupled to separation techniques and its high sensitivity. Whereas VS is widely employed for in situ studies, due to its nondestructive character. Metabolomics applications in different science fields are growing each year, due to advances in analytical techniques and combination with other omics that allow to increase the comprehension of metabolic processes. Further development of analytical tools is necessary to continue exploiting all the possibilities of metabolomics.pt_PT
dc.description.sponsorshipThe research leading to these results received financial support from Programa de Cooperación Interreg V-A Espa~na—Portugal (POCTEP) 2014–2020 (projects Ref.: 0181_NANOEATERS_01_E and Ref: 0377_IBERPHENOL_6_E); MICINN supporting the Ramón&Cajal grant for M.A. Prieto (RYC-2017-22891); Xunta de Galicia and University of Vigo supporting the post-doctoral grant for M. Fraga- Corral (ED481B-2019/096) and the pre-doctoral grants for A.G. Pereira (ED481A-2019/0228) and P. García-Oliveira (ED481A-2019/295); Xunta de Galicia through the Axudas Conecta Peme supported the IN852A 2018/58 NeuroFood Project; the company AlgaMar (www.algamar. com); EcoChestnut Project (ErasmusþKA202) that supports the work of M. Carpena; Ibero-American Program on Science and Technology (CYTED - AQUA-CIBUS, P317RT0003); the Bio Based Industries Joint Undertaking (JU) under grant agreement No 888003 UP4HEALTH Project (H2020-BBI-JTI-2019), the JU receives support from the European Union’s Horizon 2020 research and innovation program and the Bio Based Industries Consortium.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFraga-Corral, Maria; Carpena, Maria; Garcia-Oliveira, Paula; Pereira, Antia Gonzalez; Prieto Lage, Miguel A.; Simal-Gandara, Jesus (2022). Analytical metabolomics and applications in health, environmental and food science. Critical Reviews in Analytical Chemistry. ISSN 1040-8347. 52:4, p. 712-734pt_PT
dc.identifier.doi10.1080/10408347.2020.1823811pt_PT
dc.identifier.eissn1547-6510
dc.identifier.issn1040-8347
dc.identifier.urihttp://hdl.handle.net/10198/29341
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.relationSustainable and cost-effective production process for the upcycling of olive, grape and nut by-products into 4 natural and healthy ingredients for nutraceutical and cosmetic applications
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMetabolomicspt_PT
dc.subjectMetabolitept_PT
dc.subjectNuclear magnetic resonancept_PT
dc.subjectMass spectrometrypt_PT
dc.subjectVibrational spectroscopypt_PT
dc.subjectApplicationspt_PT
dc.titleAnalytical metabolomics and applications in health, environmental and food sciencept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSustainable and cost-effective production process for the upcycling of olive, grape and nut by-products into 4 natural and healthy ingredients for nutraceutical and cosmetic applications
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/888003/EU
oaire.citation.endPage734pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage712pt_PT
oaire.citation.titleCritical Reviews in Analytical Chemistrypt_PT
oaire.citation.volume52pt_PT
oaire.fundingStreamH2020
person.familyNameFraga-Corral
person.familyNamePrieto Lage
person.givenNameMaria
person.givenNameMiguel A.
person.identifier1054547
person.identifier107688
person.identifier.ciencia-id1616-98AD-4546
person.identifier.ciencia-id221E-1E00-AB74
person.identifier.orcid0000-0002-5663-9239
person.identifier.orcid0000-0002-3513-0054
person.identifier.ridG-7335-2017
person.identifier.ridG-4516-2011
person.identifier.scopus-author-id56346469200
person.identifier.scopus-author-id35937495700
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication446f0a90-be7c-4111-9949-42475fda0e6a
relation.isAuthorOfPublication13260615-fd28-4b8b-9dd4-8a8466007579
relation.isAuthorOfPublication.latestForDiscovery446f0a90-be7c-4111-9949-42475fda0e6a
relation.isProjectOfPublication9980c0d6-0317-49a0-a44d-b8aedf2294a5
relation.isProjectOfPublication.latestForDiscovery9980c0d6-0317-49a0-a44d-b8aedf2294a5

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