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Advisor(s)
Abstract(s)
A simple tailor-made protocol to synthesize graphene-based magnetic nanoparticles
(GbMNPs) for nanomedicine is herein reported. Different GbMNPs with very distinctive
physicochemical and toxicological properties were synthesized by adjusting the number of carbon
precursors in the coating of superparamagnetic iron oxide nanoparticles. In vitro tests show
the ability to use these GbMNPs as intelligent and on-demand drug nanocarrier systems for
drug delivery, exhibiting the following features: good colloidal stability, good loading capacity
of the chemotherapeutic drug doxorubicin, high pH-controlled release of the encapsulated drug
(targeting tumour acidic pH conditions), superparamagnetic behaviour and biocompatibility. Due to
their combined properties (i.e., physicochemical, magnetic, and biocompatibility), GbMNPs show
high potentiality to be combined with other biomedical techniques, such as magnetic hyperthermia,
which can represent an enhancement in the treatment of cancer.
Description
Keywords
Graphene magnetic nanocomposites Drug delivery DOX cancer
Citation
Rodrigues, Raquel Oliveira; Baldi, Giovanni; Doumett, Saer; Gallo, Juan; Bañobre-López, Manuel; Dražić, Goran; Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Lima, R.; Silva, Adrián; Gomes, Helder (2018). A Tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine. C - Journal of Carbon Research. ISSN 2311-5629. 4:4, p. 1-15