Publication
A Tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine
| dc.contributor.author | Rodrigues, Raquel Oliveira | |
| dc.contributor.author | Baldi, Giovanni | |
| dc.contributor.author | Doumett, Saer | |
| dc.contributor.author | Gallo, Juan | |
| dc.contributor.author | Bañobre-López, Manuel | |
| dc.contributor.author | Dražić, Goran | |
| dc.contributor.author | Calhelha, Ricardo C. | |
| dc.contributor.author | Ferreira, Isabel C.F.R. | |
| dc.contributor.author | Lima, Rui A. | |
| dc.contributor.author | Silva, Adrián | |
| dc.contributor.author | Gomes, Helder | |
| dc.date.accessioned | 2020-01-03T12:04:26Z | |
| dc.date.available | 2020-01-03T12:04:26Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | A simple tailor-made protocol to synthesize graphene-based magnetic nanoparticles (GbMNPs) for nanomedicine is herein reported. Different GbMNPs with very distinctive physicochemical and toxicological properties were synthesized by adjusting the number of carbon precursors in the coating of superparamagnetic iron oxide nanoparticles. In vitro tests show the ability to use these GbMNPs as intelligent and on-demand drug nanocarrier systems for drug delivery, exhibiting the following features: good colloidal stability, good loading capacity of the chemotherapeutic drug doxorubicin, high pH-controlled release of the encapsulated drug (targeting tumour acidic pH conditions), superparamagnetic behaviour and biocompatibility. Due to their combined properties (i.e., physicochemical, magnetic, and biocompatibility), GbMNPs show high potentiality to be combined with other biomedical techniques, such as magnetic hyperthermia, which can represent an enhancement in the treatment of cancer. | pt_PT |
| dc.description.sponsorship | R.O.R. acknowledges the Ph.D. scholarship SFRH/BD/97658/2013 granted by FCT. G.D. acknowledges financing by Slovene Research Agency (J2-6754). The authors also would like to acknowledge the financial support provided by COST—European Cooperation in Science and Technology, in the form of a short term scientific mission (STSM) granted by COST Action TD1402: RADIOMAG. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Rodrigues, Raquel Oliveira; Baldi, Giovanni; Doumett, Saer; Gallo, Juan; Bañobre-López, Manuel; Dražić, Goran; Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Lima, R.; Silva, Adrián; Gomes, Helder (2018). A Tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine. C - Journal of Carbon Research. ISSN 2311-5629. 4:4, p. 1-15 | pt_PT |
| dc.identifier.doi | 10.3390/c4040055 | pt_PT |
| dc.identifier.issn | 2311-5629 | |
| dc.identifier.uri | http://hdl.handle.net/10198/20005 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.relation | MAGNETIC CARBON NANOSTRUCTURES AND STUDY OF THEIR TRANSPORT IN MICROFLUIDIC DEVICES FOR HYPERTHERMIA | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | pt_PT |
| dc.subject | Graphene magnetic nanocomposites | pt_PT |
| dc.subject | Drug delivery | pt_PT |
| dc.subject | DOX cancer | pt_PT |
| dc.title | A Tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | MAGNETIC CARBON NANOSTRUCTURES AND STUDY OF THEIR TRANSPORT IN MICROFLUIDIC DEVICES FOR HYPERTHERMIA | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F97658%2F2013/PT | |
| oaire.citation.issue | 4 | pt_PT |
| oaire.citation.title | C - Journal of Carbon Research | pt_PT |
| oaire.citation.volume | 4 | pt_PT |
| person.familyName | Calhelha | |
| person.familyName | Ferreira | |
| person.familyName | Gomes | |
| person.givenName | Ricardo C. | |
| person.givenName | Isabel C.F.R. | |
| person.givenName | Helder | |
| person.identifier | 144781 | |
| person.identifier.ciencia-id | F313-E3CE-554E | |
| person.identifier.ciencia-id | 9418-CF95-9919 | |
| person.identifier.ciencia-id | 6218-1E19-13EE | |
| person.identifier.orcid | 0000-0002-6801-4578 | |
| person.identifier.orcid | 0000-0003-4910-4882 | |
| person.identifier.orcid | 0000-0001-6898-2408 | |
| person.identifier.rid | J-2172-2014 | |
| person.identifier.rid | E-8500-2013 | |
| person.identifier.scopus-author-id | 6507978333 | |
| person.identifier.scopus-author-id | 36868826600 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | 2d5d1a41-7561-4a01-871c-b4c97da35053 | |
| relation.isAuthorOfPublication | bd0d1537-2e03-41fb-b27a-140af9c35db8 | |
| relation.isAuthorOfPublication | 0eb96337-224a-4339-9918-334436fbbb99 | |
| relation.isAuthorOfPublication.latestForDiscovery | 0eb96337-224a-4339-9918-334436fbbb99 | |
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