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Determination of the cell-free layer in circular PDMS microchannels
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Orientador(es)
Resumo(s)
In microcirculation the cell-free layer is believed to reduce the friction between red blood cells (RBCs) and endothelial
cells and consequently reduce blood flow resistance. However, the complex formation of the cell-free layer has not
yet been convincingly described mainly due to multi-physical and hemorheological factors that affect this phenomenon.
In this experimental work, we study the effect of hematocrit (Hct) on the thickness of the cell-free layer in straight circular
polydimethylsiloxane (PDMS) microchannels. The channels studied are 73 ± 2 mm in diameter, flexible and circular
to mimic blood vessels. The images are captured using confocal microscopy and are post-processed using Image J and
MATLAB. The formation of a cell-free layer is clearly visible in the images captured and by using a combination of image
analysis techniques we are able to detect an increase in the cell-free layer thickness as Hct decreases.
Descrição
Palavras-chave
Cell-free layer Microchannels
Contexto Educativo
Citação
Cerdeira, T.; Lima, R.; Oliveira, M.; Monteiro, Fernando C.; Ishikawa, T.; Imai, Y.; Yamaguchi, T. (2010). Determination of the cell-free layer in circular PDMS microchannels. In COMPUTATIONAL VISION AND MEDICAL IMAGING PROCESSING VIP Image. Porto. ISBN 978-0-415-57041-1.
Editora
Taylor and Francis