Publication
Separation of nadolol stereoisomers by fixed-bed and continuous preparative liquid chromatography using C18 columns
| dc.contributor.author | Ribeiro, António E. | |
| dc.contributor.author | Arafah, Rami | |
| dc.contributor.author | Rodrigues, Alírio | |
| dc.contributor.author | Pais, Luís S. | |
| dc.date.accessioned | 2018-04-20T13:42:44Z | |
| dc.date.available | 2018-04-20T13:42:44Z | |
| dc.date.issued | 2016 | |
| dc.description.abstract | In recent years, the authors have focused in the preparative separation of chemical drugs by chiral SMB chromatography. Different case studies have been considered, including the separation of non-steroidal anti-inflammatory drugs (ketoprofen and flurbiprofen enantiomers) [1-4], and the pseudo-binary separation of nadolol stereoisomers, a beta-blocker pharmaceutical drug [5]. While the first two case studies are typical examples of binary chiral mixtures (a pair of enantiomers), the last is an example of a quaternary mixture, composed by two pairs of enantiomers. This considerably increases the complexity and the difficulty of the separation process, asking for new strategies for the complete resolution of all the four components. | pt_PT |
| dc.description.sponsorship | Financial support by the Portuguese R&D foundation FCT (Fundação para a Ciência e a Tecnologia) and European Community through FEDER (project PTDC/EQU-EQU/119025/2010) is gratefully acknowledged. This work was co-financed by FCT/MEC and FEDER under Program PT2020 (Project UID/EQU/50020/2013) and by QREN, ON2 and FEDER (Project NORTE-07-0162-FEDER-000050). Arafah, R. thanks to the Global Platform for Syrian Students. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Ribeiro, António E.; Arafah, Rami; Rodrigues, A.E.; Pais, L.S. (2014). Separation of nadolol stereoisomers by fixed-bed and continuous preparative liquid chromatography using C18 columns. In XVI Latin-American Congress on Chromatography & 9th National Meetoing on Chromatography. Lisbon | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10198/17140 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.title | Separation of nadolol stereoisomers by fixed-bed and continuous preparative liquid chromatography using C18 columns | pt_PT |
| dc.type | conference poster | |
| dspace.entity.type | Publication | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FEQU-EQU%2F119025%2F2010/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/5876/UID%2FEQU%2F50020%2F2013/PT | |
| oaire.fundingStream | 5876-PPCDTI | |
| oaire.fundingStream | 5876 | |
| person.familyName | Ribeiro | |
| person.familyName | Arafah | |
| person.familyName | Pais | |
| person.givenName | António E. | |
| person.givenName | Rami | |
| person.givenName | Luís S. | |
| person.identifier.ciencia-id | 3211-D5B0-870D | |
| person.identifier.ciencia-id | AB16-ECBF-B886 | |
| person.identifier.ciencia-id | 421E-0CCD-A84F | |
| person.identifier.orcid | 0000-0003-4569-7887 | |
| person.identifier.orcid | 0000-0002-7743-4988 | |
| person.identifier.orcid | 0000-0002-3000-2862 | |
| person.identifier.scopus-author-id | 23390701300 | |
| person.identifier.scopus-author-id | 57151342900 | |
| person.identifier.scopus-author-id | 6603930478 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |
| relation.isAuthorOfPublication | 52666376-f100-4407-87ef-dc5df3613761 | |
| relation.isAuthorOfPublication | 3cd4864a-8aa6-46a2-9415-767a7551ee62 | |
| relation.isAuthorOfPublication | c6d25534-8487-45b1-90af-d350f4e3ac55 | |
| relation.isAuthorOfPublication.latestForDiscovery | 3cd4864a-8aa6-46a2-9415-767a7551ee62 | |
| relation.isProjectOfPublication | 6c53da1e-721d-4bc6-8e9d-7e74b8d7c6eb | |
| relation.isProjectOfPublication | 66ec3fc3-043e-4147-a64b-3d87442cc076 | |
| relation.isProjectOfPublication.latestForDiscovery | 6c53da1e-721d-4bc6-8e9d-7e74b8d7c6eb |