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Advisor(s)
Abstract(s)
In recent years, the authors have focused in the preparative
separation of chemical drugs by chiral SMB chromatography.
Different case studies have been considered, including the
separation of non-steroidal anti-inflammatory drugs (ketoprofen and
flurbiprofen enantiomers) [1-4], and the pseudo-binary separation of
nadolol stereoisomers, a beta-blocker pharmaceutical drug [5]. While
the first two case studies are typical examples of binary chiral
mixtures (a pair of enantiomers), the last is an example of a
quaternary mixture, composed by two pairs of enantiomers. This
considerably increases the complexity and the difficulty of the
separation process, asking for new strategies for the complete
resolution of all the four components.
Description
Keywords
Citation
Ribeiro, António E.; Arafah, Rami; Rodrigues, A.E.; Pais, L.S. (2014). Separation of nadolol stereoisomers by fixed-bed and continuous preparative liquid chromatography using C18 columns. In XVI Latin-American Congress on Chromatography & 9th National Meetoing on Chromatography. Lisbon