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Resumo(s)
Several new terpenylpurine derivatives were prepared through alkylation of different purines with
halogenated reagents derived from natural terpenoids, commercially available or isolated from cones of
C. sempervirens L. and further transformed into appropriate alkylated agents. Alkylation of the purines
gave mixtures of 9- and 7-alkylpurines, being the 9-alkylpurines the major regioisomers. The presence of
the terpenyl residue induced cytotoxicity on simple purines and, in general, that activity improved as the
substituent was larger. The 7-diterpenyl-6-chloropurine E-21b was the most cytotoxic in the series and
it can be considered an analogue of the marine natural compounds agelasines and agelasimines, which
were taken as models for this work.
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Contexto Educativo
Citação
Valles, Elena; García, Pablo A.; Miguel del Corral, José María; Pérez, Marta; Ferreira, Isabel C.F.R.; Calhelha, Ricardo C.; San Feliciano, Arturo; Castro, María Ángeles (2016). Synthesis and cytotoxic evaluation of new terpenylpurines. RSC Advances. ISSN 2046-2069. 107:6, p. 105412-105420
Editora
Royal Society of Chemistry