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Synthesis and cytotoxic evaluation of new terpenylpurines

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dc.contributor.authorValles, Elena
dc.contributor.authorGarcía, Pablo A.
dc.contributor.authorMiguel del Corral, José María
dc.contributor.authorPérez, Marta
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorSan Feliciano, Arturo
dc.contributor.authorCastro, María Ángeles
dc.date.accessioned2016-12-22T11:04:48Z
dc.date.available2016-12-22T11:04:48Z
dc.date.issued2016
dc.description.abstractSeveral new terpenylpurine derivatives were prepared through alkylation of different purines with halogenated reagents derived from natural terpenoids, commercially available or isolated from cones of C. sempervirens L. and further transformed into appropriate alkylated agents. Alkylation of the purines gave mixtures of 9- and 7-alkylpurines, being the 9-alkylpurines the major regioisomers. The presence of the terpenyl residue induced cytotoxicity on simple purines and, in general, that activity improved as the substituent was larger. The 7-diterpenyl-6-chloropurine E-21b was the most cytotoxic in the series and it can be considered an analogue of the marine natural compounds agelasines and agelasimines, which were taken as models for this work.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationValles, Elena; García, Pablo A.; Miguel del Corral, José María; Pérez, Marta; Ferreira, Isabel C.F.R.; Calhelha, Ricardo C.; San Feliciano, Arturo; Castro, María Ángeles (2016). Synthesis and cytotoxic evaluation of new terpenylpurines. RSC Advances. ISSN 2046-2069. 107:6, p. 105412-105420
dc.identifier.doi10.1039/C6RA24254Ept_PT
dc.identifier.urihttp://hdl.handle.net/10198/13641
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherRoyal Society of Chemistrypt_PT
dc.relationBIO/SA59/15pt_PT
dc.relationSA028A10-2pt_PT
dc.relationCTQ2015-68175-Rpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleSynthesis and cytotoxic evaluation of new terpenylpurinespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberPEst-OE/AGR/UI0690/2014
oaire.awardNumberSFRH/BPD/68344/2010
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/PEst-OE%2FAGR%2FUI0690%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F68344%2F2010/PT
oaire.citation.endPage105420pt_PT
oaire.citation.issue107pt_PT
oaire.citation.startPage105412pt_PT
oaire.citation.titleRSC Advancespt_PT
oaire.citation.volume6pt_PT
oaire.fundingStream5876
oaire.fundingStreamSFRH
person.familyNameFerreira
person.familyNameCalhelha
person.givenNameIsabel C.F.R.
person.givenNameRicardo C.
person.identifier144781
person.identifier.ciencia-id9418-CF95-9919
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0002-6801-4578
person.identifier.ridE-8500-2013
person.identifier.ridJ-2172-2014
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id6507978333
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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