Repository logo
 
Publication

Study of the phenolic profile and bioactive potential of cardoon bracts as a promising functional ingredient

2022Conference object Open access
Simple item page
dc.contributor.authorMandim, Filipa
dc.contributor.authorPetropoulos, Spyridon Α.
dc.contributor.authorPinela, José
dc.contributor.authorDias, Maria Inês
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorBarros, Lillian
dc.date.accessioned2022-07-12T15:52:58Z
dc.date.available2022-07-12T15:52:58Z
dc.date.issued2022
dc.description.abstractThe world population has been growing and, consequently, so have the nutritional and food needs. The balance between adequate supply and the planet's resources is a subject with increasing attention in the world. The development of new strategies to combat this problem and ensure the population's nutritional needs are urgent and extremely necessary. The most complete characterization of crop species and their potential is extremely important for the adequate use of resources and the valorization of bio-waste generated annually through the development of new functional products [1]. Cynara cardunculus L. is a species widely cultivated in the Mediterranean region, and its production has an economic impact on this region. It is widely consumed in the Mediterranean cuisine as a result of its high nutritional value and the medicinal properties it has been demonstrating [1,2]. Cardoon bracts (variable altilis) were collected at the principal growth stage (PGS) 5. The phenolic composition was evaluated by HPLC-DAD-ESI/MS. Two in vitro assays were used to evaluate the antioxidant potential: TBARS (thiobarbituric acid reactive substances formation inhibition) and OxHLIA (oxidative hemolysis inhibition). The antiproliferative capacity was evaluated by the colorimetric method of sulforhodamine B, using several tumor cells lines and in a primary culture of non-tumor cells (PLP2). The anti-inflammatory activity was evaluated using a murine macrophage cell line (RAW 264.7). Eleven phenolic compounds were tentatively identified, with the compounds 5-O-caffeoylquinic and 3,5-O-dicaffeoylquinic acids present in higher abundance (6.362 and 21.83 mg/g extract, respectively). The cardoon bracts demonstrated cytotoxic (GI50 of 30 – 79 μg/mL) and anti-inflammatory (IC50 of 72 μg/mL) potential. The capacity to inhibit the formation of TBARS (IC50 = 26.8 μg/mL) and the oxidative hemolysis (IC50 of 82 and 159 μg/mL at Δt=60 min and 120 min, respectively) were also demonstrated. The results obtained allow us to confirm the high bioactive potential associated with cardoon bracts, as well as the great variety in phenolic compounds. These results also showed the promising potential of this species for its exploitation in the fortification of food products, such as bakery products and others. Therefore, the newly acquired knowledge allows the application of less used and less studied species as functional ingredients, and at the same time, obtain food products with richer nutritional value and higher interest for the food industry. Nevertheless, further studies are needed to better understand the compounds responsible for the observed activities, to reveal the mechanisms involved in these activities, as well as to evaluate the incorporation of this material in new functional food products.pt_PT
dc.description.sponsorshipTo the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020); for the F. Mandim PhD grant (SFRH/BD/146614/2019), and the J. Pinela (CEECIND/01011/2018) and M.I. Dias and L. Barros contracts through the individual and institutional scientific employment program-contract, respectively.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMandim, Filipa; Petropoulos, Spyridon Α.; Pinela, José; Dias, Maria Inês; Ferreira, Isabel C.F.R.; Santos-Buelga, Celestino; Barros, Lillian (2022). Study of the phenolic profile and bioactive potential of cardoon bracts as a promising functional ingredient. In Trends in grain-based foods: Book of abstracts. Bragançapt_PT
dc.identifier.isbn978-972-745-299-6
dc.identifier.urihttp://hdl.handle.net/10198/25640
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherInstituto Poitécnico de Bragançapt_PT
dc.relationMountain Research Center
dc.relationIntegrated strategies for the development of a novel functional beverage with sustainable production systems
dc.relationNot Available
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCardoon Bractspt_PT
dc.titleStudy of the phenolic profile and bioactive potential of cardoon bracts as a promising functional ingredientpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleIntegrated strategies for the development of a novel functional beverage with sustainable production systems
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F146614%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2018/CEECIND%2F01011%2F2018%2FCP1578%2FCT0002/PT
oaire.citation.conferencePlaceBragançapt_PT
oaire.citation.endPage71pt_PT
oaire.citation.startPage71pt_PT
oaire.citation.titleTrends in grain-based foods: Book of abstractspt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC IND 2018
person.familyNameMandim
person.familyNamePinela
person.familyNameDias
person.familyNameFerreira
person.familyNameBarros
person.givenNameFilipa
person.givenNameJosé
person.givenNameMaria Inês
person.givenNameIsabel C.F.R.
person.givenNameLillian
person.identifier144781
person.identifier469085
person.identifier.ciencia-idF318-9049-EB99
person.identifier.ciencia-id771C-2B43-B108
person.identifier.ciencia-id2A13-4BE6-C7CF
person.identifier.ciencia-id9418-CF95-9919
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0002-6494-2326
person.identifier.orcid0000-0001-7523-1637
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridB-4466-2014
person.identifier.ridM-8242-2013
person.identifier.ridE-8500-2013
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id54392272800
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id35236343600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicationbcc274d4-7e6c-46a8-8e49-2752f9dbfbcd
relation.isAuthorOfPublication706cd9ff-065b-4c98-98a7-5c0a9e45adc4
relation.isAuthorOfPublication7ca8432b-e7f4-4116-a56e-9eba0d4403bd
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublication.latestForDiscovery3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isProjectOfPublication29718e93-4989-42bb-bcbc-4daff3870b25
relation.isProjectOfPublication6f42bb4f-993a-4998-afc5-030cd08f965b
relation.isProjectOfPublicationec142c57-5163-4512-9a14-7319866da393
relation.isProjectOfPublication.latestForDiscoveryec142c57-5163-4512-9a14-7319866da393

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Oral Int. 166_Filipa_Mandim.pdf
Size:
467.92 KB
Format:
Adobe Portable Document Format
Download

Collections

CIMO - Resumos em Proceedings Não Indexados à WoS/Scopus