Autores
Mandim, Filipa
Dias, Maria Inês
Fernandes, Ângela
Pinela, José
Orientador(es)
Resumo(s)
Cynara cardunculus L. (cardoon) has several health benefits mainly attributed to its abundance in polyphenols. In
this study, cardoon heads (capitula) were harvested in Greece during the flowering stage, and the hydroethanolic
extracts were assessed in terms of phenolic compounds composition and antioxidant, cytotoxic, anti-inflammatory,
and antimicrobial activities. The phenolic profile was evaluated by HPLC-DAD-ESI/MS to better
understand the seasonal changes in the individual compound levels and how these changes correlate with
bioactive properties. The main phenolic compounds identified were caffeoylquinic and dicaffeoylquinic acid
derivatives. Immature heads (Car A: principal growth stage (PGS) 5) had the highest phenolic content (34.3 mg/
g) and cytotoxic (GI50 of 69–268 μg/mL) and anti-inflammatory (IC50 of 183 μg/mL) activities. Sample Car D
(PGS 6/7) revealed the highest antioxidant (IC50 of 23–227 μg/mL) and antifungal (MIC of 0.26–0.51 mg/mL)
potential. Regarding the antibacterial activity, Car E (PGS 7) revealed the best results (MIC of 0.59–1.18 mg/
mL). This study suggests that the maturity stage of the plant influences the phenolic composition and bioactivity.
Descrição
Palavras-chave
Anti-inflammatory activity Antimicrobial properties Bioactive properties Cynara cardunculus (L.) Phenolic compounds Seasonal variation
Contexto Educativo
Citação
Mandim, Filipa; Petropoulos, Spyridon A.; Giannoulis, Kyriakos D.; Dias, Maria Inês; Fernandes, Ângela; Pinela, José; Kostic, Marina; Soković, Marina; Barros, Lillian; Santos-Buelga, Celestino; Ferreira, Isabel C.F.R. (2020). Seasonal variation of bioactive properties and phenolic composition of Cynara cardunculus var. altilis. Food Research International. ISSN 0963-9969. 134, p. 1-8