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Seasonal variation of bioactive properties and phenolic composition of Cynara cardunculus var. altilis

2020Journal article Open access
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dc.contributor.authorMandim, Filipa
dc.contributor.authorPetropoulos, Spyridon Α.
dc.contributor.authorGiannoulis, Kyriakos D.
dc.contributor.authorDias, Maria Inês
dc.contributor.authorFernandes, Ângela
dc.contributor.authorPinela, José
dc.contributor.authorKostić, Marina
dc.contributor.authorSoković, Marina
dc.contributor.authorBarros, Lillian
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2020-06-22T10:18:09Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2020-06-22T10:18:09Z
dc.date.issued2020
dc.description.abstractCynara cardunculus L. (cardoon) has several health benefits mainly attributed to its abundance in polyphenols. In this study, cardoon heads (capitula) were harvested in Greece during the flowering stage, and the hydroethanolic extracts were assessed in terms of phenolic compounds composition and antioxidant, cytotoxic, anti-inflammatory, and antimicrobial activities. The phenolic profile was evaluated by HPLC-DAD-ESI/MS to better understand the seasonal changes in the individual compound levels and how these changes correlate with bioactive properties. The main phenolic compounds identified were caffeoylquinic and dicaffeoylquinic acid derivatives. Immature heads (Car A: principal growth stage (PGS) 5) had the highest phenolic content (34.3 mg/ g) and cytotoxic (GI50 of 69–268 μg/mL) and anti-inflammatory (IC50 of 183 μg/mL) activities. Sample Car D (PGS 6/7) revealed the highest antioxidant (IC50 of 23–227 μg/mL) and antifungal (MIC of 0.26–0.51 mg/mL) potential. Regarding the antibacterial activity, Car E (PGS 7) revealed the best results (MIC of 0.59–1.18 mg/ mL). This study suggests that the maturity stage of the plant influences the phenolic composition and bioactivity.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationMandim, Filipa; Petropoulos, Spyridon A.; Giannoulis, Kyriakos D.; Dias, Maria Inês; Fernandes, Ângela; Pinela, José; Kostic, Marina; Soković, Marina; Barros, Lillian; Santos-Buelga, Celestino; Ferreira, Isabel C.F.R. (2020). Seasonal variation of bioactive properties and phenolic composition of Cynara cardunculus var. altilis. Food Research International. ISSN 0963-9969. 134, p. 1-8en_EN
dc.identifier.doi10.1016/j.foodres.2020.109281en_EN
dc.identifier.issn0963-9969
dc.identifier.urihttp://hdl.handle.net/10198/14676
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.subjectAnti-inflammatory activityen_EN
dc.subjectAntimicrobial propertiesen_EN
dc.subjectBioactive propertiesen_EN
dc.subjectCynara cardunculus (L.)en_EN
dc.subjectPhenolic compoundsen_EN
dc.subjectSeasonal variationen_EN
dc.titleSeasonal variation of bioactive properties and phenolic composition of Cynara cardunculus var. altilisen_EN
dc.typejournal article
dspace.entity.typePublication
person.familyNameMandim
person.familyNameDias
person.familyNameFernandes
person.familyNamePinela
person.familyNameBarros
person.familyNameFerreira
person.givenNameFilipa
person.givenNameMaria Inês
person.givenNameÂngela
person.givenNameJosé
person.givenNameLillian
person.givenNameIsabel C.F.R.
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person.identifier.scopus-author-id36868826600
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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