Orientador(es)
Resumo(s)
Infection is one of the major risk factors for the development of chronic wounds.
Antimicrobial wound dressing has been pointed out as a viable option for the prevention
and treatment of wound infections. Thus, we developed a composite material
based on cotton textile substrates functionalized with cyclodextrin‐hydroxypropyl
methyl cellulose‐based hydrogel. The composites' ability to encapsulate and release
gallic acid (antimicrobial phenolic acid) was evaluated, as well as their mechanical
properties and antimicrobial and anti‐inflammatory capacity. All composites were able
to retain gallic acid in their structure, with similar loading profile. The presence of gallic
acid on composites was confirmed by FTIR and TGA. Composites storage moduli
was reduced by the presence of gallic acid. The results suggest a straight relation
between the swelling ability and gallic acid drug delivery profile. The drug delivery
mechanism, of the developed composites, was mainly controlled by Fickian diffusion,
based on the experimental data fitting to the Peppas‐Sahlin model. Gallic acid antimicrobial
and anti‐inflammatory properties were transferred to the composite materials.
According to the results, the developed composites can be applied on the prevention
or treatment of chronic wounds.
Descrição
Palavras-chave
Anti-inflammatory Antimicrobial Chronic wound Composite wound dressing Gallic acid Infection
Contexto Educativo
Citação
Pinho, Eva; Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Soares, Graça (2018). Cotton-hydrogel composite for improved wound healing: Antimicrobial activity and anti-inflammatory evaluation—Part 2. Polymers for Advanced Technologies. ISSN 1042-7147. , p.