Sit-to-stand test to assess muscle strength after intradialytic exercises in  chronic kidney disease patients: a systematic review with meta-analysis

Chronic kidney patients undergoing hemodialysis (HD) experience a decline in muscle strength and functionality, as musculoskeletal disorders affect both strength and functional capacity. This study aims to evaluate the influence of intradialytic (ID) exercise on the strength and functionality of chronic kidney patients, as assessed by sit-to-stand test, and to identify the most commonly used sit-to-stand protocol. Methods: A search was conducted across eight databases to identify relevant studies published before March 29, 2024. Clinical trials investigating intradialytic exercises and utilizing the sitto-stand test as an assessment tool were eligible. The risk of bias in individual studies was assessed using the Physiotherapy Evidence Database (PEDro) scale. Mean differences (MD) and 95% confidence intervals were calculated and pooled in meta-analyses. The quality of metaanalyses was assessed using the Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) approach. Results: A total of 6717 studies were initially identified. After screening,17 articles involving 870 participants, met the inclusion criteria demonstrating acceptable methodological quality, with a mean PEDro scale of 5,23 (±1,56). Despite the lack of robust evidence, this review suggests that the ID exercise improves strength and functionality. Among the various sit-to-stand test subtypes, the 10-repetition sit-to-stand test was found to be the most effective. Conclusion: Despite the low quality of studies, the 10-repetition sit-to-stand test (10-STS) seems to be the most effective for evaluating muscle strength of lower limbs and functionality. ID exercise seems to positively impact muscle strength and, consequently, the functionality of chronic kidney disease patients undergoing HD.

Keywords

Chronic kidney disease Exercise Hemodialysis Physical Functional Performance Muscle Strength Sit-to-Stand Test

URI

http://hdl.handle.net/10198/34493

Citation

Almeida, Klebson da Silva; Costa, Natália Silva; Lima, Bráulio Nascimento; Neves, José Leonardo dos Reis ; Barreto, Luiz Gustavo Pereira; Freitas, Luana de Jesus ; Silva, Monique Mesquita; Maneschy, Mariela de Santana; Novo, André; Chiavegato, Luciana Dias (2025). Sit-to-stand test to assess muscle strength after intradialytic exercises in chronic kidney disease patients: a systematic review with meta-analysis. Journal of Bodywork & Movement Therapies. ISSN 1360-8592