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Antibody response among portuguese healthcare workers prior to sars-cov-2 vaccine booster administration

2022Conference object Open access
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dc.contributor.authorPereira, Tifany
dc.contributor.authorCaldeira, Maria João
dc.contributor.authorRodrigues, A.
dc.contributor.authorAlves, Madalena
dc.contributor.authorGonçalves, Viviane
dc.contributor.authorPinto, S.
dc.contributor.authorMontanha, Maria José
dc.contributor.authorTeixeira, Cristina
dc.contributor.authorRodrigues, Carina
dc.date.accessioned2022-10-03T14:53:21Z
dc.date.available2022-10-03T14:53:21Z
dc.date.issued2022
dc.description.abstractPrioritizing healthcare workers (HCWs) for vaccination against the coronavirus disease 2019 (COVID-19) allowed to study the vaccine effectiveness in this professional group. The quantification of antibodies levels after vaccination among HCWs could give insights about SARS-CoV-2 protection. The aim of this study is to investigate SARS-CoV-2 immune response based on quantitation of antibodies against the spike receptor binding domain (RBD) of the S protein (anti-SRBD) and nucleocapside (anti-N) after the first vaccination stage in HCWs from the Local Health Unit of the Northeast of Portugal. Methods: Serum samples from 427 vaccinated HCW were tested for anti-SARS-CoV-2 immunoglobulin with chemiluminescent microparticle SARS-CoV-2 2 IgG I (anti-N) and IgG II (anti-SRBD) immunoassays detected by using ARCHITECT i1000SR (Abbot) equipment. Blood samples were collected between November and December of 2021, before the administration of 3rd vaccine dose. The chemiluminescent reaction anti-N immunoassay was expressed as an index classified as positive for values higher than 0.6. Anti-SRBD was quantified between 21.0 and 40,000.0 arbitrary units per ml (AU/mL) and values ≥ 50 AU/ml were considered positive. We obtained data about age, gender), infection with SARS-CoV-2 (PCR+), smoking habits and number of days between complete vaccination and blood sample collection Median, interquartile interval IIQ) and frequencies were obtained. Multivariate regression linear model was conducted to assess the factors affecting the values of anti-SRBD (logarithmized variable). Results: From all 427 HCW with median age 45.7 years [IIQ: 37.8-55.0], 89 (20.8%) were males, 89 (20.8%) had PCR+, 422 (98.8%) and 46 (21%) tested positive for IgG anti-SRBD and anti-N, respectively. The median of anti- SRBD was 737.3 (IIQ: 376.2-2270.1). According to the multivariate regression analysis, anti-SRBD values decrease as increase age (p = 0.004) and number of days since vaccination (p =0.004). Also, be a smoker decreases but a PCR+ increases anti-SRBD values. Conclusions/Recommendations: The SARS-CoV-2 antibody measurements suggested that quantitative anti-SRBD responses fall over the time (from days of complete immunization) and are lower among older vaccinated HCW.pt_PT
dc.description.sponsorshipProjetos de Investigação Científica e Desenvolvimento Tecnológico (IC&DT). (Programa Testar com Ciência e Solidariedade: COVID-19 - 02/SAICT/2020/072562).
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPereira, Tiffany; Caldeira, M; Rodrigues, A; Alves, M; Gonçalves, V; Pinto, S; Montanha, M; Teixeira, Cristina; Rodrigues, Carina (2022). Antibody response among portuguese healthcare workers prior to sars-cov-2 vaccine booster administration. In XL Reunion Anual de la Sociedad Espanola de Epidemiologia (SEE) y XVII Congresso da Associacao Portuguesa de Epidemiologia (APE). San Sebastián/Donostiapt_PT
dc.identifier.issn0213-9111
dc.identifier.urihttp://hdl.handle.net/10198/25958
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSESApt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntibody responsept_PT
dc.subjectSARS-Cov2 vaccinept_PT
dc.subjectHealthcare workerspt_PT
dc.titleAntibody response among portuguese healthcare workers prior to sars-cov-2 vaccine booster administrationpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceSan Sebastián/Donostia.pt_PT
oaire.citation.endPage157pt_PT
oaire.citation.startPage157pt_PT
oaire.citation.titleXL Reunión Anual de la Sociedad Española de Epidemiología (SEE) y XVII Congresso da Associação Portuguesa de Epidemiología (APE)pt_PT
oaire.citation.volume36pt_PT
person.familyNamePereira
person.familyNameTeixeira
person.familyNameRodrigues
person.givenNameTifany
person.givenNameCristina
person.givenNameCarina
person.identifier.ciencia-id5911-07B2-AE34
person.identifier.ciencia-id6E12-F2A0-568F
person.identifier.ciencia-idC415-C677-0253
person.identifier.orcid0000-0001-7213-2131
person.identifier.orcid0000-0001-5194-5141
person.identifier.orcid0000-0001-9773-1413
person.identifier.ridO-2296-2013
person.identifier.scopus-author-id55207402700
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication6fda887f-f3b7-40a6-88bd-a048019772d7
relation.isAuthorOfPublication9037c83c-43c1-4714-ad3e-9f307dd1d89f
relation.isAuthorOfPublicationef666665-6593-48be-bc48-6a1bb58bedbd
relation.isAuthorOfPublication.latestForDiscovery6fda887f-f3b7-40a6-88bd-a048019772d7

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