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Optimized ultrasound-assisted extraction of phenolic compounds from Thymus comosus Heuff. ex Griseb. et Schenk (wild thyme) and their bioactive potential

2022Journal article Open access
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dc.contributor.authorBabotă, Mihai
dc.contributor.authorFrumuzachi, Oleg
dc.contributor.authorGâvan, Alexandru
dc.contributor.authorIacoviță, Cristian
dc.contributor.authorPinela, José
dc.contributor.authorBarros, Lillian
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorZhang, Leilei
dc.contributor.authorLucini, Luigi
dc.contributor.authorRocchetti, Gabriele
dc.contributor.authorTanase, Corneliu
dc.contributor.authorCrişan, Gianina
dc.contributor.authorMocan, Andrei
dc.date.accessioned2022-03-09T16:53:26Z
dc.date.available2022-03-09T16:53:26Z
dc.date.issued2022
dc.description.abstractAn optimized ultrasound-assisted extractive method was developed to obtain a polyphenol-enriched extract from the aerial parts of Thymus comosus Heuff. ex Griseb. et Schenk. Optimization process was conducted based on Design of Experiment (DoE) principles, determining the influence of three independent variables (time, ultrasound amplitude, ethanol concentration) on the total phenolic content of the extract (dependent variable). Additionally, the phenolic composition of the extract was characterized through UHPLC-HRMS, revealing beside the most abundant flavonoid-type compounds the presence of salvianolic acids C, D and L in high amounts. Phytochemical profile of the extract was correlated with its antioxidant activity (tested through five complementary assays) and enzyme-inhibitory potential, showing important antiglucosidase and anticholinesterase effects. Overall, it was concluded that the developed method is suitable for obtaining a good recovery of both phenolic and non-phenolic compounds from Thymus comosus aerial parts, and their presence in the optimized extract is responsible for its pharmacological potential.pt_PT
dc.description.sponsorshipThis work was supported by a grant of the Romanian Ministry of Education and Research, CNCS – UEFISCDI, project number PN-III-P1- 1.1-PD-2019-1245, within PNCDI III”. The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020), and for the contracts of J. Pinela (CEECIND/01011/2018) and L. Barros (institutional scientific employment program-contract).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBabotă, Mihai; Frumuzachi, Oleg; Gâvan, Alexandru; Iacoviță, Cristian; Pinela, José; Barros, Lillian; Ferreira, Isabel C.F.R.; Zhang, Leilei; Lucini, Luigi; Rocchetti, Gabriele; Tanase, Corneliu; Crișan, Gianina; Mocan, Andrei (2022). Optimized ultrasound-assisted extraction of phenolic compounds from Thymus comosus Heuff. ex Griseb. et Schenk (wild thyme) and their bioactive potential. Ultrasonics Sonochemistry. ISSN 1350-4177. 84, p. 1-10pt_PT
dc.identifier.doi10.1016/j.ultsonch.2022.105954pt_PT
dc.identifier.issn1350-4177
dc.identifier.urihttp://hdl.handle.net/10198/25188
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationMountain Research Center
dc.relationNot Available
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectThymus comosus Heuff. ex Griseb. et Schenkpt_PT
dc.subjectUltrasound-assisted extractionpt_PT
dc.subjectOptimisationpt_PT
dc.subjectDesign of Experimentspt_PT
dc.subjectPhenolic compoundspt_PT
dc.subjectResearch Subject Categories::FORESTRY, AGRICULTURAL SCIENCES and LANDSCAPE PLANNING::Product science::Food sciencept_PT
dc.titleOptimized ultrasound-assisted extraction of phenolic compounds from Thymus comosus Heuff. ex Griseb. et Schenk (wild thyme) and their bioactive potentialpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2018/CEECIND%2F01011%2F2018%2FCP1578%2FCT0002/PT
oaire.citation.startPage105954pt_PT
oaire.citation.titleUltrasonics Sonochemistrypt_PT
oaire.citation.volume84pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC IND 2018
person.familyNamePinela
person.familyNameBarros
person.familyNameFerreira
person.givenNameJosé
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifier469085
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person.identifier.ciencia-id771C-2B43-B108
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0001-7523-1637
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridB-4466-2014
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id54392272800
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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