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Resumo(s)
Thienopyridine skeleton has been reported as havi ng inte resting
biological activity, namely antitumorlll and antiangiogenic121
activities. Herein, we describe the synth esis of thienopyridine arylethers
la-f in moderate to good yields by a copper-cata lyzed
C- 0 coupling, using N,N-dimethylglycine as a ligand, of the
7-bromothieno[3,2-b]pyridine, also prepared with substituted
phenols (see scheme).
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Contexto Educativo
Citação
Calhelha, Ricardo C.; Peixoto, Daniela; Soares, Pedro; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Queiroz, Maria João R.P. (2012). Thieno[3,2-b]pyridine arylethers: synthesis and growth inhibitory activity on human tumor cell lines. In XXIInd International Symposium on Medicinal Chemistry. Berlin