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Flow of red blood cells through a microfluidic extensional device: an image analysis assessment

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dc.contributor.authorYaginuma, Tomoko
dc.contributor.authorPereira, Ana I.
dc.contributor.authorRodrigues, Pedro João
dc.contributor.authorLima, Rui A.
dc.contributor.authorOliveira, Mónica S.N.
dc.contributor.authorIshikawa, Takuji
dc.contributor.authorYamaguchi, Takami
dc.date.accessioned2014-09-09T10:52:09Z
dc.date.available2014-09-09T10:52:09Z
dc.date.issued2012
dc.description.abstractThe present study aims to assess the deformability of red blood cells (RBCs) under extensionally dominated microfluidic flows using an image based technique. For this purpose, a microchannel having a hyperbolic shaped-contraction was used and the images were captured by a standard high-speed microscopy system. The images acquired display RBCs with various light intensity levels and image analysis was used to quantify the deformation index (DI) of the RBCs considering these light intensity differences. Additionally, the velocities of different intensity-level RBCs flowing along the centerline of the channel were measured using particle tracking velocimetry. The preliminary results at two different flow rates reveal a highly deformable nature of RBCs when submitted to strong extensional flows. It was also observed that the low intensity cells exhibit a slightly higher velocity than intermediate intensity cells, which we attribute to the cells being located in different planespor
dc.description.sponsorshipWe thank Dr. Matsuki for help \Vith blood sample collection. Additionally, wc acknowledge the financiai support provided by 2007 GlobalCOE Program "Global Nano-BME Education and Research Network", Japan. We are also thankful to FCT (Portugal) and COMPETE ror financiai support through projects PTDC/SAU-BEB/I08728/2008, PTDC/SAU-BEB/105650/2008 and PTDC/EMEMFEl099I 09/2008.
dc.identifier.citationYaginuma, T.; Pereira, Ana I.; Rodrigues, P. J.; Lima, R.; Oliveira, M.S. N.; Ishikawa, T.; Yamaguchi, T. (2012). Flow of red blood cells through a microfluidic extensional device: an image analysis assessment. In VIPIMAGE - III ECCOMAS Thematic Conference on Computational Vision and Medical Image Processing. Olhão: Taylor&Francis. p. 217-220. ISBN 978-0-415-68395-1por
dc.identifier.isbn978-0-415-68395-1
dc.identifier.urihttp://hdl.handle.net/10198/10363
dc.language.isoporpor
dc.peerreviewedyespor
dc.publisherTaylor and Francispor
dc.relationPTDC/EME-MFE/0991097/2008
dc.relationHemo-Networks - Experimental and computational investigations of the factors influencing blood flow in microvascular networks.
dc.subjectRed blood cellspor
dc.subjectDeformation indexpor
dc.subjectHyperbolic microchannelpor
dc.subjectExtensional flowpor
dc.titleFlow of red blood cells through a microfluidic extensional device: an image analysis assessmentpor
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleHemo-Networks - Experimental and computational investigations of the factors influencing blood flow in microvascular networks.
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-BEB%2F108728%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-BEB%2F105650%2F2008/PT
oaire.citation.conferencePlaceOlhãopor
oaire.citation.endPage220por
oaire.citation.startPage217por
oaire.citation.title3rd ECCOMAS Thematic Conference on Computational Vision and Medical Image Processingpor
oaire.fundingStream5876-PPCDTI
oaire.fundingStream5876-PPCDTI
person.familyNamePereira
person.familyNameRodrigues
person.familyNameLima
person.givenNameAna I.
person.givenNamePedro João
person.givenNameRui A.
person.identifier.ciencia-id0716-B7C2-93E4
person.identifier.ciencia-id1316-21BB-9015
person.identifier.ciencia-idEE12-C3FB-349D
person.identifier.orcid0000-0003-3803-2043
person.identifier.orcid0000-0002-0555-2029
person.identifier.orcid0000-0003-3428-637X
person.identifier.ridF-3168-2010
person.identifier.ridH-5157-2016
person.identifier.scopus-author-id15071961600
person.identifier.scopus-author-id18437397800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
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