Orientador(es)
Resumo(s)
As a continuation of our search for biologically active mushroom species the present study investigates in vitro
antidiabetic properties of six edible and medicinal mushroom species: Agaricus blazei Murrill, Coprinus comatus
(O.F.Müll.) Pers., Cordyceps militaris (L.) Fr., Inonotus obliquus (Ach. ex Pers.) Pilát, Morchella conica Pers. and
Phellinus linteus Berk. & M.A. Curtis. In vitro assays on α-amylase and α-glucosidase enzyme inhibition were
performed with methanolic extracts of the selected mushrooms. Furthermore, we calculated the necessary
daily intake of mushroom extracts and dry mushroom powders based on the equivalent doses of therapeutic
drug acarbose given to diabetic patients per day. Our comparative study on enzyme inhibition showed that the
most promising potential is ascribed to I. obliquus extract, while no inhibition of α-amylase was recorded with
M. conica and C. militaris methanolic extract at the tested concentration. This comparative study is the first
highlighting in vitro antidiabetic potential by inhibition of α-amylase and α-glucosidase with methanolic extracts;
which makes the investigated speciesmore promising for the diabetes type-2 treatment by an additional
and different mechanism of action.
Descrição
Palavras-chave
Diabetes mellitus Edible and medicinal Mushroom α-Amylase α-Glucosidase
Contexto Educativo
Citação
Stojkovic, D.; Smiljkovic, M.; Ciric, A.; Glamoclija, J.; Van Griensven, L.; Ferreira, I. C.F.R.; Sokovic, M. (2019). An insight into antidiabetic properties of six medicinal and edible mushrooms: Inhibition of α-amylase and α-glucosidase linked to type-2 diabetes. South African Journal of Botany. ISSN 0254-6299. 120, p. 100-103