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Cosmeceutical properties of p-hydroxybenzoic acid and use of microencapsulation technique to ensure controlled release

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dc.contributor.authorTaofiq, Oludemi
dc.contributor.authorHeleno, Sandrina A.
dc.contributor.authorSilva, Ana Rita
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorFernandes, Isabel P.
dc.contributor.authorAlves, Maria José
dc.contributor.authorGonzález-Paramás, Ana María
dc.contributor.authorBarros, Lillian
dc.contributor.authorBarreiro, M.F.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2021-10-22T13:20:10Z
dc.date.available2021-10-22T13:20:10Z
dc.date.issued2019
dc.description.abstractTopical formulations are designed to exert multifunctional benefits to the skin, and the interest on natural bioactive compounds as cosmeceutical ingredients have recently received increased attention [1]. However, the utilization of natural ingredients can present constraints related to their stability (e.g. against pH and temperature), being microencapsulation a useful strategy to overcome some of these limitations [2]. The present work describes p-hydroxybenzoic acids anti-inflammatory, anti-tyrosinase, and antimicrobial activity. The compound was further microencapsulated using the atomization/coagulation method, with sodium alginate coagulated with calcium chloride. The obtained microspheres were characterized in terms of morphology, particle size distribution, and encapsulation efficiency. Free and microencapsulated forms were then incorporated into a semisolid cosmetic base formulation and HPLC-DAD was used to screen the presence of the compound in the final formulation. p-Hydroxybenzoic acid showed anti-inflammatory (EC50 = 195 ± 9 μg/mL), anti-tyrosinase (EC50 = 1.86 ± 0.01 mg/mL), and antimicrobial activity against a panel of Gram positive and Gram negative bacteria, and also Candida albicans. The microparticles showed spherical morphology, with various sizes (D10, D50 and D90 representing 20.5, 74.6, and 206 μm, respectively), little agglomeration, and a unimodal and bimodal particle size distribution (number and volume, respectively). Encapsulation efficiency and yield were 88.3% and 57.8%, respectively. After incorporation, the formulation containing free forms of the compound maintained some of its bioactive properties, while the encapsulated forms preserved the bioactivity showing a slow release profile of the compounds. In conclusion, the studied compound showed interesting bioactive properties and can be used in the development of multifunctional cosmeceutical formulation. The adopted encapsulation strategy also provides a suitable alternative to prolong retention of bioactive compounds for subsequent release (sustained release), thereby preserving its bioactivity over time.pt_PT
dc.description.sponsorshipFCT and FEDER under Program PT2020 (POCI-COMPETE2020) for CIMO (UID/AGR/00690/2019) and Associate Laboratory LSRE-LCM (UID/EQU/50020/2019) funded by national funds through FCT/MCTES (PIDDAC). European Structural and Investment Funds (FEEI) through NORTE 2020 (Project Mobilizador ValorNatural®). This work is funded by the European Agricultural Fund for Rural Development (EAFRD), through the Rural Development Program (PDR2020), within the scope of Project MicoCoating (PDR2020-101-031472). L. Barros. R.M. Calhelha and I. Fernandes thank the national funding by FCT, P.I., through the institutional scientific employment program-contract for their contracts, while S. Heleno thanks the national funding by FCT, P.I., through the individual scientific employment program-contract.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTaofiq, Oludemi; Heleno, Sandrina A.; Silva, Ana Rita; Calhelha, Ricardo C.; Fernandes, Isabel P.; Alves, Maria José; González- Paramás, Ana M.; Barros, Lillian; Barreiro, Maria Filomena; Ferreira, Isabel C.F.R. (2019). Cosmeceutical properties of p-hydroxybenzoic acid and use of microencapsulation technique to ensure controlled release. In XXV Encontro Galego-Portugués de Química. ISBN 978-84-09-16320-5pt_PT
dc.identifier.isbn978-84-09-16320-5
dc.identifier.urihttp://hdl.handle.net/10198/24070
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationMountain Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectp-hydroxybenzoic acidpt_PT
dc.subjectCosmeceutical propertiespt_PT
dc.titleCosmeceutical properties of p-hydroxybenzoic acid and use of microencapsulation technique to ensure controlled releasept_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardNumberUID/AGR/00690/2019
oaire.awardTitleMountain Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FAGR%2F00690%2F2019/PT
oaire.citation.conferencePlaceSantiago de Compostela, Espanhãpt_PT
oaire.citation.titleEncontro Galego-Português de Químicapt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameHeleno
person.familyNameSilva
person.familyNameCalhelha
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person.familyNameBarros
person.familyNameBarreiro
person.familyNameFerreira
person.givenNameSandrina A.
person.givenNameAna Rita
person.givenNameRicardo C.
person.givenNameIsabel P.
person.givenNameMaria José
person.givenNameLillian
person.givenNameFilomena
person.givenNameIsabel C.F.R.
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
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