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Effect of chaetomellic acid on hematocrit, urine specific gravity and urinary volume values in a rat model of renal mass reduction

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dc.contributor.authorNogueira, António José M.
dc.contributor.authorRocha, Ana Isabel Faustino
dc.contributor.authorTeixeira-Guedes, Catarina
dc.contributor.authorTeixeira, Joana H.
dc.contributor.authorOliveira, Paula A.
dc.contributor.authorColaço, Bruno Jorge
dc.contributor.authorPires, Maria João
dc.date.accessioned2014-09-29T08:52:03Z
dc.date.available2014-09-29T08:52:03Z
dc.date.issued2012
dc.description.abstractChaetomellic acid (CA) is a potent and highly specific inhibitor of ras farnesyl-protein transferase that seems to reduce both functional and histological damage in uninephrectomized rats subjected to renal ischaemia-reperfusion injury. The aim of this work was to evaluate the effect of chronic treatment with CA on hematocrit, urine specific gravity and urinary volume in a model of renal mass reduction. Male Wistar rats were subjected to 5/6 nephrectomy (RMR) or sham-operated (SO). One week after surgery, rats have been placed in four experimental groups: RMR rats without treatment (n=13); RMR rats treated with CA (n=13); SO rats without treatment (n=13); SO rats treated with CA (n=13). CA was intraperitoneally administered in a dose of 0.23 μg/kg three times a week for three months. We observed that animals from SO groups showed a higher hematocrit and urine specific gravity, and a lower urinary volume than animals from RMR groups (p<0.05). We did not observe differences between treated and no treated animals. These results suggest that three months of treatment with CA does not have a beneficial effect on hematocrit, urine specific gravity and urinary volume. However, these are preliminary data that warrant a larger scale study.por
dc.identifier.citationNogueira, António José M.; Faustino-Rocha, Ana; Teixeira-Guedes, Catarina; Teixeira, Joana; Oliveira, Paula; Colaço, Bruno; Pires, Maria (2012) – Effect of chaetomellic acid on hematocrit, urine specific gravity and urinary volume values in a rat model of renal mass reduction. In VI Jornadas de Biologia. Vila Realpor
dc.identifier.urihttp://hdl.handle.net/10198/10632
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherUniversidade de Trás-os-Montes e Alto Douro - UTADpor
dc.subjectChaetomellic acidpor
dc.subjectRatpor
dc.titleEffect of chaetomellic acid on hematocrit, urine specific gravity and urinary volume values in a rat model of renal mass reductionpor
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceVila Realpor
oaire.citation.titleVI Jornadas de Biologiapor
person.familyNameNogueira
person.givenNameAntónio José M.
person.identifier.ciencia-id8A11-794E-36BD
person.identifier.orcid0000-0001-8912-7355
person.identifier.scopus-author-id55865568268
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
relation.isAuthorOfPublication648209a2-eec9-4bec-975a-32673e41b95c
relation.isAuthorOfPublication.latestForDiscovery648209a2-eec9-4bec-975a-32673e41b95c

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