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Resumo(s)
A number of thienopyrimidines derivatives have shown potent VEGFR2 (Vascular
Endothelium Growth Factor Receptor2) tyrosine kinase inhibition activity.[ll VEGF is a
sun·ogate marker of angiogenesis that activates VEGFR2 in endothelial cells.
Here we present the synthesis of new 1-aryl-3-[ 4-(thieno[3,2-d]pyrimidin-4-
yloxy)phenyl]ureas from the aminodi(hetero)arylether 1, also prepared by us, which was
reacted with arylisocyanates to give the corresponding 1,3-diarylureas 2a-c.
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Contexto Educativo
Citação
Peixoto, Daniela; Calhelha, Ricardo C.; Soares, Pedro; Abreu, Rui M.V.; Froufe, Hugo J.C.; Ferreira, Isabel C.F.R.; Costa, Raquel; Soares, Raquel; Queiroz, Maria João (2012). 1-Aryl-3-[ 4-( thieno[3,2-d]pyrimidin-4-yloxy )phenyl]ureas as VEG FR2 inhibitors: synthesis, docking enzymatic and cellular assays. In 3º Encontro Nacional de Química Terapêutica e 1st Portuguese-Spanish-Brazilian Meeting on Medicinal Chemistry. Aveiro
Editora
Universidade de Aveiro