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Flow visualizations in polydimethylsiloxane cerebral aneurysm biomodels
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Orientador(es)
Resumo(s)
This chapter focuses on the study of intracranial aneurysms (IAs), which are localized dilations of arteries within the skull caused by weakened blood vessel walls. IAs pose a significant risk of rupture, leading to strokes with high mortality and dependency rates. The chapter emphasizes the importance of understanding the hemodynamics and geometry of blood vessels to prevent aneurysm rupture.
The authors present an innovative technique for manufacturing intracranial aneurysm biomodels using Polysmooth as a sacrificial material and polydimethylsiloxane (PDMS) for the final model. PDMS is chosen for its transparency, flexibility, and ease of manufacturing, which facilitates flow visualization tests. The biomodels are designed with different geometric configurations (60° and 180° angles between inlet and outlet channels) to analyze the effects of channel geometry on blood flow patterns.
The experimental setup includes high-speed video equipment, an inverted microscope, and a syringe pump to simulate blood flow using a glycerol-water solution with suspended particles. The flow visualization tests reveal differences in recirculation areas within the aneurysm based on the channel geometry, highlighting the impact of arterial structure on hemodynamics.
The study concludes that the presented manufacturing technique is effective for creating realistic biomodels, enabling detailed analysis of blood flow behavior in aneurysms. This research provides valuable insights for developing numerical models and strategies to prevent aneurysm rupture
Descrição
Palavras-chave
Intracranial Aneurysm (IA) Polydimethylsiloxane (PDMS) Flow Visualization Hemodynamics
Contexto Educativo
Citação
Souza, A.; Nobrega, G.; Conrado, F.; Puga, H.; Lima, R.; Ribeiro, J.E. (2026). Flow visualizations in polydimethylsiloxane cerebral aneurysm biomodels. In Recent Advances in Hemodynamics and Blood Mimetics. p. 361-367. ISBN 978-0-443-24066-9
Editora
Elsevier