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Flow visualizations in polydimethylsiloxane cerebral aneurysm biomodels

2026Capítulo de livro Acesso restrito
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datacite.subject.fosEngenharia e Tecnologia::Engenharia Mecânica
datacite.subject.fosEngenharia e Tecnologia::Engenharia Médica
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
dc.contributor.authorSouza, Andrews
dc.contributor.authorNobrega, Glauco
dc.contributor.authorFerrera, Conrado
dc.contributor.authorPuga, Helder
dc.contributor.authorLima, Rui A.
dc.contributor.authorRibeiro, J.E.
dc.date.accessioned2026-03-30T15:55:53Z
dc.date.available2026-03-30T15:55:53Z
dc.date.issued2026
dc.description.abstractThis chapter focuses on the study of intracranial aneurysms (IAs), which are localized dilations of arteries within the skull caused by weakened blood vessel walls. IAs pose a significant risk of rupture, leading to strokes with high mortality and dependency rates. The chapter emphasizes the importance of understanding the hemodynamics and geometry of blood vessels to prevent aneurysm rupture. The authors present an innovative technique for manufacturing intracranial aneurysm biomodels using Polysmooth as a sacrificial material and polydimethylsiloxane (PDMS) for the final model. PDMS is chosen for its transparency, flexibility, and ease of manufacturing, which facilitates flow visualization tests. The biomodels are designed with different geometric configurations (60° and 180° angles between inlet and outlet channels) to analyze the effects of channel geometry on blood flow patterns. The experimental setup includes high-speed video equipment, an inverted microscope, and a syringe pump to simulate blood flow using a glycerol-water solution with suspended particles. The flow visualization tests reveal differences in recirculation areas within the aneurysm based on the channel geometry, highlighting the impact of arterial structure on hemodynamics. The study concludes that the presented manufacturing technique is effective for creating realistic biomodels, enabling detailed analysis of blood flow behavior in aneurysms. This research provides valuable insights for developing numerical models and strategies to prevent aneurysm ruptureeng
dc.description.sponsorshipFinancial support was provided by Portugal’s national funding FCT/MCTES (PIDDAC) to Centro de Investigação de Montanha (CIMO) (UIDB/00690/2020 and UIDP/00690/2020) and SusTEC (LA/P/0007/2020). The authors additionally acknowledge the project PTDC (https://doi.org/10.54499/2022.06207.PTDC), for the financial support, through national funds (OE), within the scope of the Scientific Research and Technological Development Projects (IC&DT) program in all scientific domains (PTDC), PORTUGAL 2020 Partnership Agreement, European Regional Development Fund (FEDER), via the Foundation for Science and Technology, I.P. (FCT, I.P) and the R&D Units projects, UIDB/04077/2020, UIDB/00532/2020, and LA/P/0045/2020 (ALiCE).C. Ferrera gratefully acknowledges funding from the Junta de Extremadura through grant IB20105 (partially funded by FEDER) Glauco Nobrega was supported by the doctoral Grant PRT/BD/153088/2021 (https://doi.org/10.54499/PRT/D/153088/2021) financed by the Portuguese Foundation for Science and Technology (FCT), under MIT Portugal Program. Andrews Souza was supported by FCT - Foundation for Science and Technology, I.P. by project reference 2021.07961.BD and DOI identifier https://doi.org/10.54499/2021.07961.BD.
dc.identifier.citationSouza, A.; Nobrega, G.; Conrado, F.; Puga, H.; Lima, R.; Ribeiro, J.E. (2026). Flow visualizations in polydimethylsiloxane cerebral aneurysm biomodels. In Recent Advances in Hemodynamics and Blood Mimetics. p. 361-367. ISBN 978-0-443-24066-9
dc.identifier.doi10.1016/B978-0-443-24066-9.00001-5
dc.identifier.isbn978-0-443-24066-9
dc.identifier.urihttp://hdl.handle.net/10198/36404
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.relationMechanical Engineering and Resource Sustainability Center
dc.relationTransport Phenomena Research Center
dc.relationALICE - Associate Laboratory in Chemical Engineering
dc.relationSeaweed nanofluids for cooling photovoltaic solar panels used in space missions (PRT/BD/153088/2021)
dc.relationi9Models: Development of innovative in vitro models to study the wall deformability and blood flow in aneurysms.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectIntracranial Aneurysm (IA)
dc.subjectPolydimethylsiloxane (PDMS)
dc.subjectFlow Visualization
dc.subjectHemodynamics
dc.titleFlow visualizations in polydimethylsiloxane cerebral aneurysm biomodelseng
dc.typebook part
dspace.entity.typePublication
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oaire.awardNumberLA/P/0045/2020
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oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardTitleMechanical Engineering and Resource Sustainability Center
oaire.awardTitleTransport Phenomena Research Center
oaire.awardTitleALICE - Associate Laboratory in Chemical Engineering
oaire.awardTitleSeaweed nanofluids for cooling photovoltaic solar panels used in space missions (PRT/BD/153088/2021)
oaire.awardTitlei9Models: Development of innovative in vitro models to study the wall deformability and blood flow in aneurysms.
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oaire.citation.endPage367
oaire.citation.startPage361
oaire.citation.titleRecent Advances in Hemodynamics and Blood Mimetics
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person.familyNameRibeiro
person.givenNameJ.E.
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