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Cytinus hypocistis L. plant as source of phenolic compounds with anti-lipid peroxidation activity

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dc.contributor.authorSilva, Ana Rita
dc.contributor.authorDias, Maria Inês
dc.contributor.authorGarcia, Pablo A.
dc.contributor.authorBarros, Lillian
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2019-01-04T14:09:02Z
dc.date.available2019-01-04T14:09:02Z
dc.date.issued2018
dc.description.abstractAfter a period in which synthetic compounds were preferred, there is an increasing interest m studyüig the bioactive properties of plants and the active principies behind their therapeutic properties [l]. Polyphenols are the largest and the most widespread group of secondary metabolites in plants. With a great variety of structures, ranging from simple compounds with few aromatic rings, such as phenolic acids, to highly polymeric substances, such as tannins; they are commonly found in both edible and inedible plants, and have been reported to have multiple biological effects, including antioxidant activity [2]. Cytinus hypocistis L. is an endophytic parasitic plant occurring in the Mediterranean region and it was used in a wide variety of traditional healthcare practices, induding dysentery, tumour of the throat and eye inflammation treatment [3]. Despite these wealthy traditional uses, its chemical composiüon is largely unknown. Therefore, the aim of this study was to characterize this plant in terms of polyphenolic composition and capacity to inhibit lipid peroxidation. Plant specimens were coUected in June 2018 in Castro Daire, Portugal. After lyophilisation, the phenolic compounds were analysed in four diíFerent hydroethanolic extracts ofC. hypocistis (whole plant, nectar chamber of thef lower,p etals, ands talks) usinga nH PLC-DAD/ESI-MSs ystem. Seventeenp henolic compounds were identified, sbcteen hydrolyzable tannins (with trigalloyl-diHHDPglucoside as the major compound) and one flavan-3-ol ((+)-catechin), being the petals the sample that presented the highest concentration ofthe identified compounds. TBARS method was used to evaluate the inhibition of lipid peroxidation, a widely recognized primary toxicological event caused by the generation offree radicais [4]. In this study, the hydroethanolic extracts ofthe four samples were capable ofpreventing the formation ofmalondialdehyde (MDA), a secondary product oflipid peroxidation, in a dose dependent manner. The highest anti-lipid peroxidation activitywas revealed by the petals extract (342 ng/mL), also exhibiting the highest concentration ofphenolic compounds. This activity is much better than the one displayed by the standard Trolox. This study revealed that the extracts might preveni reactive radical species from damaging biomolecules such as lipids in the cells. These features are behind the health benefits for humans and the wide use of tannin-containing plant extracts in herbal medicine [5]. A correlation study will also be performed to understand the influence ofphenolic compounds in the bioactive properties ofthis plant.pt_PT
dc.description.sponsorshipThe authors are grateful to FCT and FEDER under the programme PT2020 for the financiai support to CIMO (UID/AGR/00690/2013) and L. Barras contract; FEDER-Interreg Espana- Portugal programme for financiai support through the project 0377_Iberphenol_6_E.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva, Ana Rita; Dias, Maria Inês; Garcia, Pablo A.; Barros, Lillian; Ferreira, Isabel C.F.R. (2018). Cytinus hypocistis L. plant as source of phenolic compounds with anti-lipid peroxidation activity. In XXIV Encontro Luso Galego de Química. Porto. ISBN 978-989-8124-24-1pt_PT
dc.identifier.isbn978-989-8124-24-1
dc.identifier.urihttp://hdl.handle.net/10198/18309
dc.language.isoporpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCytinus hypocistis L.pt_PT
dc.titleCytinus hypocistis L. plant as source of phenolic compounds with anti-lipid peroxidation activitypt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardNumberUID/AGR/00690/2013
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F00690%2F2013/PT
oaire.citation.conferencePlacePorto, Portugalpt_PT
oaire.citation.titleXXIV Encontro Luso Galego de Químicapt_PT
oaire.fundingStream5876
person.familyNameSilva
person.familyNameDias
person.familyNameBarros
person.familyNameFerreira
person.givenNameAna Rita
person.givenNameMaria Inês
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifierABD-5857-2020
person.identifier469085
person.identifier144781
person.identifier.ciencia-id0E1A-35C1-C79A
person.identifier.ciencia-id2A13-4BE6-C7CF
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0001-5819-9065
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridM-8242-2013
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication4b329c1a-e6c5-4e48-aac5-b19a6b91a279
relation.isAuthorOfPublication7ca8432b-e7f4-4116-a56e-9eba0d4403bd
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