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Electrochemical behavior of Hydroxyxanthones versus ROS scavenging activities
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Orientador(es)
Resumo(s)
Xanthones are a class of naturally-occurring oxygenated heterocyclic compounds
with a broad spectrum of biological activities of great interest for potential therapeutic
applications. 1 IJ Thus, over the last decades a great number of publications have emerged
focusing on the isolation and s~nthesis of these natural compounds or even in the search
for novel bioactive derivatives.1- 1
Electrochemical methodologies can be applied to establish correlations between
structure and oxidation potential of electroactive species and therefore to predict some of
its biological activities. In fact, cyclic voltammetry has become an important and widely
used electroanalytical technique in many relevant studies of redox ~rocesses for clarifying
the electrochemical behavior of chemical and biochemical systems.1 1
Herein, we will report the electrochemical behavior of several phenolic and
catecholic-substituted 2,3-diarylxanthones by cyclic voltammetry using a glassy carbon
electrode, at pH 7.4, and the results obtained compared with their scavenging activities for
reactive oxygen species (ROS) and reactive nitrogen species (RNS).141 Useful
considerations about oxidation mechanism will be highlighted and the electrochemical
profile of xanthones will corroborate their biological propetties.
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Citação
Santos, Clementina M. M.; Garcia, Beatriz; Silva, Artur; Fernandes, Eduarda (2012). Electrochemical behavior of Hydroxyxanthones versus ROS scavenging activities. In 3º Encontro Nacional de Química Terapêutica. Aveiro