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Advisor(s)
Abstract(s)
Despite the antibacterial potential of plant extracts against several bacterial infections, until now, no major
studies have been published about the effect of lavender and nettle leaves against methicillin-sensitive and
methicillin-resistant strains of Staphylococcus aureus (MSSA and MRSA, respectively). Thus, the authors studied
their antibacterial potential against MSSA and MRSA from diabetic foot ulcers in order to find alternatives to the
systematic use of antibiotics. Phenolic acids, flavonoids, flavones and flavonols were extracted from lavender
and nettle leaves and characterized by HPLC-DAD/Vis. Disc diffusion assay and minimum inhibitory
concentration (MIC) were used to assess their antibacterial activity. A direct association between the high
content of hydroxycinnamic acids (chlorogenic acid, caffeic acid, rosmarinic acid) and flavonoids (quercetin)
and decreasing bacterial growth activity was noted. The fact that lavender and nettle are rich in hydroxycinnamic
acids and quercetin seems to explain the high antibacterial potential of these plant and the
differences between them.
Description
Keywords
Antibacterial activity Lavender MRSA Natural products Nettle Phytochemicals
Citation
Zenão, S.; Aires, Alfredo; Dias, Carla; Saavedra, M.J.; Fernandes, Conceição (2017). Antibacterial potential of Urtica dioica and Lavandula angustifolia extracts against methicillin resistant Staphylococcus aureus isolated from diabetic foot ulcers. Journal of Herbal Medicine. ISSN 2210-8033. 10, p. 53-58
Publisher
Elsevier