Browsing by Author "Santos, Susana"
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- Atitudes face ao Lobo IbéricoPublication . Ramos, Ricardo; Santos, Susana; Lagoaça, DoraO Lobo-ibérico (Canis lupus signatus) é classificado como "Em Perigo" em Portugal. Estima-se que existam em Portugal menos de 300 lobos. Os principais fatores responsáveis pela regressão desta subespécie nos últimos séculos foram a perseguição direta movida pelo Homem, a redução das populações de ungulados selvagens e a destruição e fragmentação do habitat. É importante compreender como as comunidades locais conhecem e entendem o comportamento deste animal. Sendo que estas acabam por vezes por partilhar o mesmo habitat. O estudo de comportamento deste animal tem sido relevante, para arranjar soluções que visem tentar solucionar a diminuição da sua população e que permitam melhorar as condições de vida dos animais. O presente estudo tem uma natureza exploratória e visa compreender as atitudes dos pastores da região de Bragança, assim como dos alunos da ESEB, face às medidas de conservação adotadas para a subespécie Canis lupus signatus. Para o efeito, elaborou-se um questionário - que foi aplicado aos dois grupos referidos (N previsto = 51) − e posteriormente utilizou-se uma folha de cálculo Excel para auxiliar nas análises estatísticas
- The cyclooxigenase-2 inhibitor parecoxib prevents epidermal dysplasia in HPV16-transgenic mice: efficacy and safety observationsPublication . Ferreira, Tiago; Campos, Sandra; Silva, Mónica; Ribeiro, Rita; Santos, Susana; Almeida, José L.S.; Pires, Maria João; Costa, Rui Miguel Gil; Córdova, Cláudia; Nogueira, António José M.; Neuparth, Maria João; Medeiros, Rui; Bastos, Margarida M.S.M.; Gaivão, Isabel; Peixoto, Francisco P.; Oliveira, Maria Manuel; Oliveira, Paula A.Carcinogenesis induced by high-risk human papillomavirus (HPV) involves inflammatory phenomena, partially mediated by cyclooxigenase-2. In pre-clinical models of HPV-induced cancer, cyclooxygenase-2 inhibitors have shown significant e cacy, but also considerable toxicity. This study addresses the chemopreventive e ect and hepatic toxicity of a specific cyclooxigensase-2 inhibitor, parecoxib, in HPV16-transgenic mice. Forty-three 20 weeks-old female mice were divided into four groups: I (HPV16+/-, n = 10, parecoxib-treated); II (HPV16+/- n = 11, untreated); III (HPV16+/-, n = 11, parecoxib-treated) and IV (HPV16+/- n = 11, untreated). Parecoxib (5.0 mg/kg once daily) or vehicle was administered intraperitoneally for 22 consecutive days. Skin lesions were classified histologically. Toxicological endpoints included genotoxic parameters, hepatic oxidative stress, transaminases and histology. Parecoxib completely prevented the onset of epidermal dysplasia in HPV16+/- treated animals (0% versus 64% in HPV16+/- untreated, p = 0.027). Parecoxib decreases lipid peroxidation (LPO) and superoxide dismutase (SOD) activity and increases the GSH:GSSG ratio in HPV16+/- treated animals meaning that oxidative stress is lower. Parecoxib increased genotoxic stress parameters in wild-type and HPV16-transgenic mice, but didn’t modify histological or biochemical hepatic parameters. These results indicate that parecoxib has chemopreventive e ects against HPV16-induced lesions while maintaining an acceptable toxicological profile in this model.
- Maternal care experience and postpartum depressive symptoms among migrant and native in PortugalPublication . Teixeira, Cristina; Santos, Susana; Guerra, João; Barros, HenriqueTo assess the association between maternal experience with healthcare (MEHC) and postpartum depressive symptoms (PPDS), taking into account the migration status.
- Maternal care experience and postpartum depressive symptoms among migrant and native in PortugalPublication . Teixeira, Cristina; Santos, Susana; Guerra, João; Barros, HenriqueMigration is a risk factor for both, poor maternal experience with healthcare services (MEHCS) and postpartum depressive symptoms (PPDS), a matter of concern due to their adverse consequences. We aimed to assess the association between MEHCS and PPDS taking into account the migration status. Methods: This is part of a population-based study (baMBINO project), enrolling native (PT; n = 1568), permanent migrant (PM; n = 676) and temporary migrant (TM; n = 757) women recruited at delivery (2017-2019) in 32 Portuguese public hospitals. MEHCS was assessed based on 39 items of the Migrant Friendly Maternal Care Questionnaire asking about how women have experienced maternal care during pregnancy, during delivery and after birth. Items were grouped into 9 components each one assessing a different issue of MEHCS. For each component women were classified as having ‘‘good’’ or ‘‘less than good’’ experience. PPDS were assessed using the Edinburgh Postnatal Depression Scale (cut-off>12).Multivariate logistic regression model was fitted to estimate the association between MEHCS and PPDS. Adjusted odds ratio (aOR) and respective 95% confidence interval were obtained. Results: PPDS were reported by 3.8%, 5.8% and 8.2% of PT, PM and TM women, respectively (p < 0.001). After adjustment, 4 out 9 components of MEHCS appeared related with PPDS, such that women reporting less than good experience with ‘‘under standing information’’ (aOR = 1.72 95%CI:1.14-2.60), ‘‘decisions according to maternal wishes’’ (aOR = 1.56 95% CI:1.04-2.34), ‘‘time waiting for healthcare’’ (aOR = 1.50 95%CI:1.04-2.18) and ‘‘healthcare provider’s attitudes during pregnancy’’ (aOR = 1.58 95%CI:1.01-2.47) showed higher odds of PPDS than women reporting good experience. Conclusions: Further than the migration status, poor experience with some issues of maternal care seems play a role in the risk of PPDS Key messages: Awareness should be given to maternal care experience. Public health strategies should address factors underlying a positive maternal experience.