Percorrer por autor "Leite, Luciano Bernardes"
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- Assessment of heart rate variability and infrared thermography in response to exercise-induced muscle damagePublication . Marques, Wanessa Karoline Brito; Santana, Paulo Vitor Albuquerque; Oliveira, Vinícius Fernandes Ferreira de; Pussieldi, Guilherme de Azambuja; Leite, Luciano Bernardes; Forte, Pedro; Assis, Miller Gomes; Pimenta, Eduardo Mendonça; Mostarda, Cristiano Teixeira; Costa, Herikson Araújo; Dibai-Filho, Almir Vieira; Oliveira Junior, Mario Norberto Sevilio; Cabido, Christian Emmanuel Torres; Veneroso, Christiano EduardoThe aim of this study is to investigate the behavior of autonomic nervous activation and infrared thermography (IR) after an eccentric exercise protocol. The sample consisted of ten physically active men (22.5 ± 3.3 years) who had not practiced plyometric training in the 6 months prior to the study. After a period of familiarization and assessment of body composition, the participants underwent a plyometric jumping protocol, including jumps over a 50 cm obstacle and jumps from a 50 cm box, after a 5-min warm-up on the treadmill. Subsequently, the following assessments were performed: assessments included measures of rating perceived fatigue (RPF), delayed-onset muscle soreness (DOMS), IRT and heart rate variability (HRV) performed at 24, 48 and 72 h after exercise. The RPF results showed a significant increase from baseline at 24 h, 48 h, and 72 h after the muscle damage protocol. For DOMS, significant increases were observed at 24 h, 48 h, and 72 h compared to baseline, with values notably higher at 24 h and 48 h than at 72 h. Thermographic assessments of the posterior thigh region showed a higher concentration of pixels in the warm zone at 48 h and 72 h compared to baseline, as well as at 48 h and 72 h compared to 24 h. Regarding HRV, the LF/HF ratio and %LF were elevated at 24 h and 48 h compared to baseline and 72 h, while %HF decreased at 24 h and 48 h relative to baseline. The exercise-induced stress increased warm-zone pixels and elevated sympathetic activity (LF/HF ratio and %LF) up to 48 h post-exercise. This was followed by a shift to increased parasympathetic modulation (higher %HF), indicating recovery. These findings underscore the utility of IRT and HRV in monitoring recovery and optimizing training.
- Associations Between Pain Intensity and Inflammatory Profile in Women with Android and Gynoid Obesity Diagnosed with Chronic Pain: An Observational StudyPublication . Cota, Cecília Cristina; Miranda-Castro, Stefani; Souza-Gomes, Antônio Felipe; Leite, Luciano Bernardes; Forte, Pedro; Monteiro, António M.; Pereira, William Valadares Campos; Moura, Samara Silva; Nunes-Silva, AlbenáThere are different types of obesity, and the metabolic conditions associated with these phenotypes are also heterogeneous. Overweight and obesity are not only associated with pain but are also identified as risk factors for the development of pain. Objective: This study aimed to compare the levels of inflammatory biomarkers, counting of immune cells, and chronic pain between android and gynoid female patients with obesity. Method: Thirty (n = 30) women took part in this study (18 androids, age: 50.61 +/- 9.41 and 12 gynoids, age: 50.67 +/- 9.45). The participants underwent anamnesis, Visual Numeric Scale (VNS), dual-energy X-ray absorptiometry, and blood sampling for the analysis of leukocytes, C-reactive protein (CRP), and interleukin (IL)-6. Results: The number of total leukocytes in the blood was not different when comparing the android group (6045 mu L) with the gynoid group (5230 mu L). No differences were observed for neutrophils (3440 mu L in android and 3017 mu L in gynoid), lymphocytes (2208 mu L in android and 2115 mu L in gynoid), for monocytes (429.7 mu L in android and 392.8 mu L in gynoid), and basophils (17.27 mu L in android and 15.41 mu L in gynoid). However, there was a significant difference between the number of eosinophils when comparing the android group (137.6 mu L) with the gynoid group (204.9 mu L), p = 0.04. Although both groups presented CRP values above 0.3 mg/dL-indicative of low-grade inflammation-no statistically significant difference was observed. Similarly, no difference was found in pain intensity between groups, as measured by the Visual Numeric Scale (VNS). Conclusions: Although most inflammatory and pain markers did not differ between groups, the higher eosinophil count in the gynoid phenotype suggests immunological distinctions between obesity types. These findings underline the importance of considering body fat distribution in clinical assessments of inflammation and chronic pain in women with obesity.
- Athletes’ origin trends in participation and performance of master runners in the New York City marathon (1999–2024): a sex- and age-group analysisPublication . Duric, Sasa; Villiger, Elias; Andrade, Marilia Santos; Leite, Luciano Bernardes; Forte, Pedro; Chlíbková, Daniela; Nikolaidis, Pantelis Theo; Weiss, Katja; Rosemann, Thomas; Knechtle, BeatIt is well known that the fastest elite marathon runners come from East African countries such as Ethiopia and Kenya. However, to date, there is no information available on the origin of the fastest age group (master) marathoners. This study aimed to determine the countries of origin of the fastest age group marathoners who have participated in the 'New York City Marathon' over the past several decades. Race data from 1,009,839 runners (626,183 male and 383,656 female finishers) who completed the 'New York City Marathon' between 1999 and 2024 were analyzed. Participants were categorized into five-year age groups: <20, 20-24, 25-29, 30-34, 35-39, 40-44, 45-49, 50-54, 55-59, 60-64, 65-69, 70-74, and 75 + years. The data were stratified by sex (male and female) and country of origin. The dataset was organized into five performance-based subgroups: (i) the entire dataset, including all finishers by age group and nationality; (ii) the top 100 finishers per age group; (iii) the top 30 finishers per age group; (iv) the top 10 finishers per age group; and (v) the top individual from each country within each age group. Regression analyses were conducted to explore demographic predictors of marathon performance. Participation generally increased over the study period, with temporary declines during the COVID-19 pandemic; male participation consistently outnumbered female participation, the 40-44 years age group was the most represented for both sexes, and participation was lowest in the youngest (< 20 years) and oldest (75 + years) age groups. Crucially, analyses focusing on the fastest age-group marathoners revealed clear nationality-based performance patterns. In younger adult age groups (20-39 years), the fastest average race times were predominantly achieved by female and male runners from Kenya and Ethiopia. The < 20 years age category showed comparatively stronger performances from European runners, including those from Poland, Switzerland and Italy. In the 50 years and older age groups, the best average times were increasingly recorded by runners from the United States of America, Japan, Germany and Switzerland. This shift highlights a regional transition in peak marathon performance with increasing age, from East African to European, North American, and East Asian dominance.
- Blueberry Extract and Resistance Training Prevent Left Ventricular Redox Dysregulation and Pathological Remodeling in Experimental Severe Pulmonary Arterial HypertensionPublication . Leite, Luciano Bernardes; Soares, Leôncio Lopes; Guimarães-Ervilha, Luiz Otávio; Costa, Sebastião Felipe Ferreira; Generoso, Sara Caco dos Lúcio; Xavier, Mirielly Alexia Miranda; Iasbik-Lima, Thainá; Oliveira, Leandro Licursi; Lucia, Ceres Mattos Della; Bianchi, Sara Elis; Bassani, Valquíria Linck; Herter, Flavio Gilberto; Turck, Patrick; Araujo, Alex Sander da Rosa; Forte, Pedro; Reis, Emily Correna Carlo; Machado-Neves, Mariana; Natali, Antônio JoséTo investigate whether the regular administration of blueberry extract and low-intensity resistance exercise training (RT), either alone or in combination, during the development of monocrotaline (MCT)-induced severe pulmonary arterial hypertension (PAH) in rats protect the left ventricle (LV) from redox dysregulation and pathological remodeling. Groups of seven male Wistar rats were formed for the experiment: sedentary control; sedentary hypertensive; sedentary hypertensive blueberry; exercise hypertensive; and exercise hypertensive blueberry. PAH was experimentally induced through a single intraperitoneal administration of MCT at a dose of 60 mg/kg. One day after injection, the blueberry groups started receiving a daily dose of blueberry extract (100 mg/kg) by gavage, while the exercise groups initiated a three-week program of RT (ladder climbing; 15 climbs carrying 60% of maximum load; one session/day; 5 times/week). Echocardiographic evaluations were conducted 23 days after injection, and the rats were euthanized the next day to harvest LV tissue. Separately, blueberry extract and RT mitigated augments in pulmonary artery resistance, LV tissue redox dysregulation (i.e., increased PC levels) and detrimental remodeling (i.e., reduced inflammation), and reductions in ejection fraction (EF) and fractional shortening (FS) caused by PAH. The combination of treatments prevented reductions in EF and FS, along with the development of a D-shaped LV. blueberry extract and moderate-intensity resistance training administered during the development of MCT-induced severe PAH in rats prevented LV redox dysregulation and pathological remodeling, thereby preserving its function.
- Combined exercise hinders the progression of pulmonary and right heart harmful remodeling in monocrotaline-induced pulmonary arterial hypertensionPublication . Leite, Luciano Bernardes; Soares, Leôncio Lopes; Portes, Alexandre Martins Oliveira; Silva, Bruna Aparecida Fonseca da; Dias, Taís Rodrigues; Soares, Thayana Inácia; Assis, Mirian Quintão; Guimarães-Ervilha, Luiz Otávio; Carneiro-Júnior, Miguel Araújo; Forte, Pedro; Machado-Neves, Mariana; Reis, Emily Correna Carlo; Natali, Antônio JoséThe aim of this study was to test whether combined physical exercise training of moderate intensity executed during the devel- opment of monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) hinders the progression of pulmonary and right heart harmful functional and structural remodeling in rats. Wistar rats were injected with MCT (60 mg/kg) and after 24 h were exposed to a combined exercise training program: aerobic exercise (treadmill running—60 min/day; 60% of maximum running speed); and resistance exercise (vertical ladder climbing—15 climbs; 60% of maximum carrying load), on alternate days, 5 days/ wk, for 3 wk. After euthanasia, the lung and right ventricle (RV) were excised and processed for histological, single myocyte, and biochemical analyses. Combined exercise increased the tolerance to physical effort (time until fatigue and relative maximum load) and prevented increases in pulmonary artery resistance (acceleration time (TA)/ejection time (TE)] and reductions in RV function [tricuspid annular plane systolic excursion (TAPSE)]. Moreover, in myocytes isolated from the RV, combined exercise pre- served contraction amplitude, as well as contraction and relaxation velocities, and inhibited reductions in the amplitude and max- imum speeds to peak and to decay of the intracellular Ca2 þ transient. Furthermore, combined exercise avoided RV (RV weight, cardiomyocyte, extracellular matrix, collagen, inflammatory infiltrate, and extracellular matrix) and lung (pulmonary alveoli and al- veolar septum) harmful structural remodeling. In addition, combined exercise restricted RV [nitric oxide (NO) and carbonyl protein (CP)] and lung [catalase (CAT), glutathione S-transferase (GST), and NO] oxidative stress. In conclusion, the applied combined exercise regime hinders the progression of pulmonary and right heart functional and structural harmful remodeling in rats with MCT-induced PAH.
- Combined nandrolone and resistance training induced cardiac remodelling and oxidative stress despite enhanced cardiomyocyte contractilityPublication . Moraes, Alexa Alves de; Suarez, Pedro Zavagli; Quintão, Arthur Eduardo de Carvalho; Fontes, Beatriz Lana; Costa, Sebastião Felipe Ferreira; Rocha, Carolina Camargos; Soares, Leôncio Lopes; Leite, Luciano Bernardes; Oliveira, Leandro Licursi; Reis, Emily Correna Carlo; Oliveira, Edilamar Menezes de; Forte, Pedro; Natali, Antônio José; Carneiro-Júnior, Miguel AraújoNandrolone decanoate (ND) is widely used by individuals engaged in resistance training (RT), yet their combined effects on cardiac function remain unclear. Objective To investigate the effects of RT and ND on cardiac structure and function, cellular contractility, Ca-2 (+) -handling protein expression, and redox balance in rats. Methods Thirty-two male Wistar rats were assigned to four groups: control (C), trained (C-T), ND (N), and trained ND (N-T). Animals received ND or saline for eight weeks, and RT was performed 3 x /week. Cardiac function was assessed by echocardiography, and isolated cardiomyocytes from the left and right ventricles (LV and RV) were evaluated for contractile function. Protein expression of Ca-2 (+) -handling regulators and oxidative stress markers was quantified. Results N-T increased LV and RV diameters by 25% and 33%, septal thickness by 41.7%, and reduced ejection fraction by 12.3% compared to N (p < 0.05). LV cardiomyocytes increased width by 29% and volume by 23% in N-T versus C-T (p <= 0.04). In LV, N-T showed greater contraction amplitude and velocity at 5 Hz (p = 0.04) and increased relaxation velocity at 1, 3, and 5 Hz (p < 0.01), with shorter time to peak contraction and 50% relaxation at 1 Hz versus N (p = 0.04). In RV, N-T increased contraction amplitude and velocity at 1 and 5 Hz, reduced time to peak at 1 and 3 Hz, shortened relaxation time at 1 Hz, and showed higher relaxation velocity than N and C-T (p < 0.02). Molecular analyses revealed reduced RyR2 expression (25% in LV and 9% in RV) and a 41% decrease in LV phospholamban in N-T versus C-T (p < 0.05). N-T also exhibited higher LV malondialdehyde compared to C-T (p = 0.03). Conclusion ND combined with RT induced adverse cardiac remodeling and impaired ventricular function, despite enhanced cardiomyocyte contractility, and intensified molecular and oxidative disturbances, indicating a maladaptive cardiac response. This is the first study to demonstrate regional differences in contractility and redox balance of isolated ventricular cardiomyocytes under ND plus RT.
- Comparative Effects of Resistance Training Modalities on Mental Health and Quality of Life in Individuals with Spinal Cord InjuryPublication . Santos, Lucas Vieira; Freitas, Karla Raphaela da Silva Ramos; Pereira, Eveline Torres; Leite, Luciano Bernardes; Forte, Pedro; Oliveira, Claudia Eliza Patrocínio de; Moreira, Osvaldo CostaBackground: Anxiety and depression are prevalent after spinal cord injury, impairing social participation and quality of life. Objective: This study aimed to investigate the effects of traditional resistance training (TRT), flywheel resistance training (FWRT), and high-velocity resistance training (HVRT) on the mental health and quality of life in individuals with spinal cord injury. Methods: Thirty-two participants were divided into TRT (n = 12), FWRT (n = 8), and HVRT (n = 12) groups, undergoing 8 weeks of upper-limb training twice weekly under super-vision. Training intensity and volume were progressively increased. The Hospital Anxiety and Depression Scale and SF-36 Questionnaire were used to assess outcomes. Results: Both the TRT and FWRT groups showed a reduction in HADS-D scores post-intervention (p < 0.001). The TRT group also presented a significant reduction in HADS-A scores post-intervention (p = 0.003). Concerning quality of life, after training, TRT showed improvements in social functioning (p = 0.013), FWRT improved scores in physical functioning (p = 0.002), bodily pain (p = 0.002), vitality (p = 0.046), and role emotional (p < 0.001), while HVRT enhanced role physical (p < 0.001), social functioning (p = 0.013), and role emotional (p < 0.001). Conclusion: Overall, TRT was the most effective in reducing anxiety and depression and enhancing quality of life, while FWRT showed notable gains in physical and functional capacity. HVRT demonstrated improvements primarily in role physical but was less effective in other domains.
- Comparative Efficacy of Bodyweight and Free Weights Training on Shooting Strength in Roller HockeyPublication . Paiva, Eduardo; Afonso, Pedro; Leite, Luciano Bernardes; Teixeira, José Eduardo; Forte, Pedro; Rodrigues, Pedro M.This study evaluated the impact of an 8-week training program on two groups of players, one performing free weights training and the other bodyweight training. The sample consisted of 14 athletes with a mean age of 22.6 years. Assessments of shooting strength were conducted before and after the program, measuring shot speed, acceleration, and strength. The free weights training included exercises with dumbbells and barbells, while the bodyweight training included squats, push- ups, and planks. Sessions occurred twice a week, with gradual progress in the number of sets and repetitions. Statistical analyses were performed using GraphPad Prism software, with significance set at p<0.05. Data distribution was tested using the Shapiro-Wilk test, and comparisons between pre- and post-intervention assessments were made with paired t- tests. Results showed significant improvements in shot speed, acceleration, and strength in the free weights training group, while the bodyweight training group showed no significant changes. It was concluded that free weights training is more effective for improving shooting strength in roller hockey players.
- Do Elite Female Judokas Show Asymmetry in the Internal and External Rotators of the Shoulder? A One-Dimensional and Principal Component ApproachPublication . Aedo-Muñoz, Esteban; Merino-Muñoz, Pablo; Leite, Luciano Bernardes; Forte, Pedro; Miarka, Bianca; Gonzalez-Valenzuela, Matias; Hernandez-Wimmer, Cristian; Arriagada-Tarifeño, DavidAsymmetry of the internal (IR) and external (ER) shoulder rotators can increase the risk of injuries in judokas. Discrete analyses are usually performed in time series data, but they can have biases by removing trends, so other approaches have been proposed to avoid these biases such as statistical parametric mapping (SPM) and principal component analysis (PCA). This study analyzed the asymmetry in the shoulder rotators in female judokas, comparing dominant (D) vs. non-dominant (ND) upper limbs. For this, 11 elite athletes (age: 20.1 ± 2.9 yrs.; experience: 4.0 ± 0.5 yrs.; body mass: 66.0 ± 14.6 kg; height: 1.6 ± 0.1 m; BMI: 24.8 ± 4.3 kg/m2), were evaluated in an isokinetic dynamometer (Cybex® Humac/Norm Dynamometer CSMI, 502140, Stoughton, MA, USA). All participants performed the concentric (CON/CON) isokinetic evaluations of internal and external rotation of the shoulder in 60◦/s and 180◦/s angular velocities. There was no significative asymmetry between IR vs. ER at 60◦/s; similar results were observed at 180◦/s when analyzed by PCA or SPM methods (p > 0.05 for all comparison). There was no difference between peak torque at 60◦/s or 180◦/s (p > 0.05 for all comparison). No asymmetry was observed in IR and ER in elite female athletes, regardless of the analysis method.
- The Effect of Flywheel Resistance Training on Executive Function in Older Women: A Randomized Controlled TrialPublication . Cota, Amanda dos Reis; Pérez Bedoya, Édison Andrés; Agostinho, Pablo Augusto Garcia; Leite, Luciano Bernardes; Schneider, André; Forte, Pedro; Monteiro, António M.; Branquinho, Luís; Teixeira, José Eduardo; Oliveira, Claudia Eliza Patrocínio de; Moreira, Osvaldo Costa; Carneiro-Júnior, Miguel AraújoExecutive function, which includes inhibitory control, working memory, and cognitive flexibility, tends to decline with aging. While traditional resistance training (TRT) has shown positive effects in mitigating these declines, limited evidence is available regarding flywheel resistance training (FRT). This study aimed to evaluate and compare the effects of TRT and FRT on executive function in older women. In this randomized controlled trial (clinicaltrials.gov NCT05910632), 29 older women were allocated into two groups: TRT (n = 15) and FRT (n = 14). The intervention lasted eight weeks with two weekly sessions conducted at the Federal University of Vi & ccedil;osa. The TRT group performed exercises using machines and free weights, while the FRT group used a multi-leg isoinertial device. Executive function was assessed using the Victoria Stroop Test (inhibitory control), Digit Span Test (working memory), and Trail Making Tests A and B (cognitive flexibility). Data were analyzed using a Multivariate Analysis of Covariance (p < 0.05). Results: No significant changes were observed in inhibitory control (p = 0.350). Working memory improved significantly within both groups in forward (p = 0.002) and backward (p = 0.002) span tasks. For cognitive flexibility, Trail Making Test A showed no significant changes (p > 0.05), but Test B showed significant within-group (p = 0.030) and between-group (p = 0.020) improvements. The B-A difference was also significant (p = 0.040). Both resistance training modalities enhanced working memory and cognitive flexibility. However, FRT produced greater improvements in cognitive flexibility, suggesting potential advantages in cognitive aging interventions.
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