Percorrer por autor "Grosso, Clara"
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- Natural antioxidants from marine sources and their application in foodsPublication . Silva, Aurora; Carpena, Maria; Grosso, Clara; Barciela, Paula; Pereira, Antía González; Cassani, Lucia; Barroso, Maria F.; Simal-Gandara, Jesus; Prieto Lage, Miguel A.This chapter provides an overview of recent studies assessing the antioxidant potential of marine organisms and their bioactive compounds to be incorporated into food products and supplements. Emphasis was given to marine flora, especially micro- and macroalgae and marine invertebrates, namely sponges, seagrasses, sea cucumbers, jellyfishes, crustaceans, and mollusks. The most relevant compounds such as vitamins A and C, polysaccharides, peptides and amino acids, phenolic compounds, and pigments (carotenoids and chlorophylls) were highlighted. Due to their biologically active compounds, these species have already been incorporated into food products available in the market like dairy products, yogurts, cookies, bread, pasta, and sausages, among others, creating a more sustainable and healthier alternative to synthetic preservatives and additives.
- Recent advances in biological properties of brown algae-derived compounds for nutraceutical applicationsPublication . Silva, Aurora; Cassani, Lucia; Grosso, Clara; Garcia-Oliveira, Paula; Morais, Stephanie L.; Echave Álvarez, Javier; Carpena Rodríguez, María; Xiao, Jianbo; Barroso, Fátima; Simal-Gandara, Jesus; Prieto Lage, Miguel A.The increasing demand for nutraceuticals in the circular economy era has driven the research toward studying bioactive compounds from renewable underexploited resources. In this regard, the exploration of brown algae has shown significant growth and maintains a great promise for the future. One possible explanation could be that brown algae are rich sources of nutritional compounds (polyunsaturated fatty acids, fiber, proteins, minerals, and vitamins) and unique metabolic compounds (phlorotannins, fucoxanthin, fucoidan) with promising biological activities that make them good candidates for nutraceutical applications with increased value-added. In this review, a deep description of bioactive compounds from brown algae is presented. In addition, recent advances in biological activities ascribed to these compounds through in vitro and in vivo assays are pointed out. Delivery strategies to overcome some drawbacks related to the direct application of algae-derived compounds (low solubility, thermal instability, bioavailability, unpleasant organoleptic properties) are also reviewed. Finally, current commercial and legal statuses of ingredients from brown algae are presented, considering future therapeutical and market perspectives as nutraceuticals.
- Tracing the path between mushrooms and Alzheimer's disease-a literature reviewPublication . Silva, Ana Margarida; Preto, Marco; Grosso, Clara; Vieira, Monica; Delerue-Matos, Cristina; Vasconcelos, Vítor; Reis, Mariana; Barros, Lillian; Martins, RosarioAlzheimer's disease (AD) is well-known among neurodegenerative diseases for the decline of cognitive functions, making overall daily tasks difficult or impossible. The disease prevails as the most common form of dementia and remains without a well-defined etiology. Being considered a disease of multifactorial origin, current targeted treatments have only managed to reduce or control symptoms, and to date, only two drugs are close to being able to halt its progression. For decades, natural compounds produced by living organisms have been at the forefront of research for new therapies. Mushrooms, which are well-known for their nutritional and medicinal properties, have also been studied for their potential use in the treatment of AD. Natural products derived from mushrooms have shown to be beneficial in several AD-related mechanisms, including the inhibition of acetylcholinesterase (AChE) and & beta;-secretase (BACE 1); the prevention of amyloid beta (A & beta;) aggregation and neurotoxicity; and the prevention of Tau expression and aggregation, as well as antioxidant and anti-inflammatory potential. Several studies in the literature relate mushrooms to neurodegenerative diseases. However, to the best of our knowledge, there is no publication that summarizes only AD data. In this context, this review aims to link the therapeutic potential of mushrooms to AD by compiling the anti-AD potential of different mushroom extracts or isolated compounds, targeting known AD-related mechanisms.