Utilize este identificador para referenciar este registo: http://hdl.handle.net/10198/826
Título: Synthesis and antimicrobial activity studies of ortho-chlorodiarylamines and heteroaromatic tetracyclic systems in the benzo[b]thiophene series
Autor: Queiroz, Maria João R.P.
Ferreira, Isabel C.F.R.
Gaetanoa, Yannick de
Kirsch, Gilbert
Calhelha, Ricardo C.
Estevinho, Leticia M.
Palavras-chave: Benzothiophenes
Ortho-chlorodiarylamines
Palladium
Thienocarbazoles
Thienocarboline
Antimicrobial activity
Data: 2006
Editora: Elsevier
Citação: Bioorganic & Medicinal Chemistry. ISSN 0968-0896. 14:20 (2006) p. 6827-6831
Resumo: ortho-Chlorodiarylamines in the 2,3,7-trimethylbenzo[b]thiophene series were prepared in high yields (70–85%) by C–N palladium-catalyzed cross-coupling using P(t-Bu)3 as ligand and NaOt-Bu as base. A palladium-assisted C–C intramolecular cyclization of the coupling products gave thienocarbazoles and the dechlorinated diarylamines. Studies of antimicrobial activity of the compounds obtained, against representative species of bacteria (Escherichia coli, Pseudomonas aeruginosa, Bacillus cereus and Bacillus subtilis) and fungi (Candida albicans), were performed. We have also included in the biological assays some pyridine derivatives previously prepared by us, and it was possible to establish some structure–activity relationships (SARs).
URI: http://hdl.handle.net/10198/826
ISSN: 0968-0896
Aparece nas colecções:BB - Artigos em Revistas Indexados ao ISI/Scopus

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
BMC cloradas.pdf134,83 kBAdobe PDFVer/Abrir


FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Degois 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.