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Please use this identifier to cite or link to this item: http://hdl.handle.net/10198/6074

Título: Mdm2 as a potential target for mushrooms LMW compounds.
Autor: Froufe, Hugo J.C.
Abreu, Rui M.V.
Ferreira, Isabel C.F.R.
Issue Date: 2011
Citação: Froufe, Hugo; Abreu, Rui M.V; Ferreira, Isabel C.F.R. (2011) - Mdm2 as a potential target for mushrooms LMW compounds. In 2nd Iberic Meeting on Medicinal Chemistry: G Protein-Coupled Receptors and Enzymes in Drug Discovery. Porto
Resumo: In some human cancer cases, the activity of p53 is inhibited by the overexpressed Mdm2 (E3 ubiquitin-protein ligase Mdm2) oncoprotein.1 Mdm2 acts as an ubiquitin ligase, resulting in p53 ubiquitination and subsequent p53 proteasomal degradation. The disruption of the Mdm2-p53 interaction using small-molecule inhibitors is recognized as a promising strategy for anticancer drug design.2 Mushrooms are a vast and yet largely untapped source of powerful new pharmaceutical products. In particular, and most importantly for modern medicine, they represent an unlimited source of compounds with antitumor and immunostimulating properties.3 In this study, a total of 85 LMW (low molecular weight) compounds present in mushrooms were used in a protein-ligand docking experiment using a Mdm2 protein structure (PDB:1T4E) as receptor protein target.
Arbitragem científica: yes
URI: http://hdl.handle.net/10198/6074
Appears in Collections:BB - Resumos em Proceedings Não Indexados ao ISI

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