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|Title:||Bee propolis effect on protection of RBC’s membrane integrity|
Pereira, Ana Paula
Estevinho, Leticia M.
|Citation:||Moreira, Leandro; Pereira, Ana Paula; Morais, Margarida; Costa, Bruno; Dias, Luis; Dias, Teresa; Estevinho, Leticia M. (2009) - Bee propolis effect on protection of rbc’s membrane integrity. In Microbiotec’09. Albufeira|
|Abstract:||Propolis is a resinous substance collected from plants by bees. The propolis composition depends on the surrounding vegetation, the season, and the area from which derive. This hive product usually contains a variety of chemical compounds such as polyphenols (flavonoids, phenolic acids and esters), steroids, and amino acids. The hereditary spherocytosis (HS) is a congenital hemolytic anemia, with origin in the modification of membrane proteins of erythrocytes, which leads to increased susceptibility to hemolysis and a decrease of the cell over-life. The HS is the most common red blood cell (RBC) membrane disorder in European Caucasians, with a prevalence of roughly 200-300 per 106, and to Japanese population 5.7-20.3 per 106. The aim of the present work was to determine if propolis extracts could affected the red cell membrane integrity and comparing the effect of two propolis extracts from different regions (Bornes - Trás-os-Montes; Fundão - Beira Interior). In this work, two adults were studied, one with the syndrome HS splenectomized and one healthy used as control. Diagnosis of HS was made by clinical features, identification of spherocytes on peripheral blood smears and abnormal osmotic fragility. The results show that the two propolis extracts affected the erythrocyte membrane fragility in both individuals (control and patient with HS).|
|Appears in Collections:||BB - Resumos em Proceedings Não Indexados ao ISI/Scopus|
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