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|Title: ||Polyhydroxy-2,3-diarylxanthones as antioxidants|
|Authors: ||Santos, Clementina M.M.|
|Issue Date: ||2008|
|Publisher: ||Universidade do Porto, Faculdade de Farmácia|
|Citation: ||Santos, Clementina; Morliere, Patrice; Silva, Artur; Maziere, Jean Claude; Cavaleiro, José; Santús, René (2008) - Polyhydroxy-2,3-diarylxanthones as antioxidants. In 1º Encontro Nacional de Química Terapêutica. Porto|
|Abstract: ||Xanthones are a class of oxygenated heterocyclic compounds widely occurring in nature. The biological properties of these compounds have been extensively reported in the literature and one of the most promising is their potential application as antioxidant agents. This fact led us to start a programme on the synthesis of 2,3-diarylxanthones bearing hydroxyl groups in certain positions of their skeleton for further structure- antioxidant activity studies.
In this communication we will describe the synthesis of 2,3-diarylxanthones starting with 2’-hydroxyacetophenone and cinnamic acid derivatives (Scheme 1). The Heck reaction of 3-bromo-2-styrylchromones 3 with styrenes give the methoxyxanthones 4 which, after cleavage of the protecting groups, give the desired polyhydroxy-2,3-diarylxanthones 5.
We will also report the inhibitory effect of the synthesized xanthones 5 on Cu2+-induced oxidation of isolated human serum low-density lipoproteins (LDLs). The formation of conjugated dienes and the consumption of carotenoids were chosen as markers of LDL lipid peroxidation. The induction of oxidative stress studies in NCTC 2544 cells will also be presented.|
|Appears in Collections:||PTV - Resumos em Proceedings Não Indexados ao ISI|
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