Publication
Polyhydroxy-2,3-diarylxanthones as antioxidants
| dc.contributor.author | Santos, Clementina M.M. | |
| dc.contributor.author | Morlière, Patrice | |
| dc.contributor.author | Silva, Artur | |
| dc.contributor.author | Maziére, Jean-Claude | |
| dc.contributor.author | Cavaleiro, José | |
| dc.contributor.author | Santus, René | |
| dc.date.accessioned | 2011-04-08T10:51:43Z | |
| dc.date.available | 2011-04-08T10:51:43Z | |
| dc.date.issued | 2008 | |
| dc.description.abstract | Xanthones are a class of oxygenated heterocyclic compounds widely occurring in nature.[1] The biological properties of these compounds have been extensively reported in the literature and one of the most promising is their potential application as antioxidant agents.[2] This fact led us to start a programme on the synthesis of 2,3-diarylxanthones bearing hydroxyl groups in certain positions of their skeleton for further structure- antioxidant activity studies. In this communication we will describe the synthesis of 2,3-diarylxanthones starting with 2’-hydroxyacetophenone and cinnamic acid derivatives (Scheme 1). The Heck reaction of 3-bromo-2-styrylchromones 3 with styrenes give the methoxyxanthones 4 which, after cleavage of the protecting groups, give the desired polyhydroxy-2,3-diarylxanthones 5.[3] We will also report the inhibitory effect of the synthesized xanthones 5 on Cu2+-induced oxidation of isolated human serum low-density lipoproteins (LDLs). The formation of conjugated dienes and the consumption of carotenoids were chosen as markers of LDL lipid peroxidation.[4] The induction of oxidative stress studies in NCTC 2544 cells will also be presented. | por |
| dc.identifier.citation | Santos, Clementina; Morliere, Patrice; Silva, Artur; Maziere, Jean Claude; Cavaleiro, José; Santús, René (2008). Polyhydroxy-2,3-diarylxanthones as antioxidants. In 1º Encontro Nacional de Química Terapêutica. Porto | por |
| dc.identifier.uri | http://hdl.handle.net/10198/3979 | |
| dc.language.iso | eng | por |
| dc.publisher | Universidade do Porto, Faculdade de Farmácia | por |
| dc.subject | Diarylxanthones | por |
| dc.subject | LDL | por |
| dc.subject | Copper oxidation | por |
| dc.subject | Oxidative stress | por |
| dc.title | Polyhydroxy-2,3-diarylxanthones as antioxidants | por |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Faculdade de Farmácia, Universidade do Porto | por |
| oaire.citation.title | 1º Encontro Nacional de Química Terapêutica | por |
| person.familyName | Santos | |
| person.givenName | Clementina M.M. | |
| person.identifier.ciencia-id | 9018-DB9C-C590 | |
| person.identifier.orcid | 0000-0003-4380-7990 | |
| person.identifier.scopus-author-id | 7201458663 | |
| rcaap.rights | openAccess | por |
| rcaap.type | conferenceObject | por |
| relation.isAuthorOfPublication | 64f662b6-775d-4ea0-bfd7-f527af0ac1a0 | |
| relation.isAuthorOfPublication.latestForDiscovery | 64f662b6-775d-4ea0-bfd7-f527af0ac1a0 |