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http://hdl.handle.net/10198/3426
Título: | Synthesis of Polyhydroxy-2,3-diarylxanthones with potencial antioxidant activity |
Autor: | Santos, Clementina M.M. Silva, Artur Cavaleiro, José |
Data: | 2006 |
Citação: | Santos, Clementina M.M.; Silva, Artur; Cavaleiro, José (2006) - Synthesis of Polyhydroxy-2,3-diarylxanthones with potencial antioxidant activity. In 4th Eurasian Meeting on Heterocyclic Chemistry. Tessalónica |
Resumo: | Xanthones are a well-studied class of heterocyclic compounds [1] and over the years these substances have been extensively studied due to their biological properties. Both natural and synthetic derivatives have shown important anti-microbial, anti-tumour, anti-inflammatory as well as antioxidant activities [2]. Several structure/activity studies of polyphenolic compounds revealed that the presence of hydroxyl substituents in certain positions of their skeleton is of great importance for a high antioxidant activity [3]. Taking this knowledge into consideration, we report the synthesis of new polyhydroxy-2,3- diarylxanthones, starting from the 3-bromo-2-methylchromone 1. Aldol condensation of 1 with benzaldehydes leads to the formation of 3-bromo-2-styrylchromones 2 followed by Heck reaction with styrenes to give the 2,3-arylxanthones 3 [4]. The final step consists in the cleavage of protective groups to obtain the desired polyhydroxy-2,3-diarylxanthones 4 |
Peer review: | yes |
URI: | http://hdl.handle.net/10198/3426 |
Aparece nas colecções: | CIMO - Resumos em Proceedings Não Indexados à WoS/Scopus |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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2006 4EMHC Poster 2.pdf | 1,74 MB | Adobe PDF | Ver/Abrir |
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