Publication
Synthesis of Polyhydroxy-2,3-diarylxanthones with potencial antioxidant activity
| dc.contributor.author | Santos, Clementina M.M. | |
| dc.contributor.author | Silva, Artur | |
| dc.contributor.author | Cavaleiro, José | |
| dc.date.accessioned | 2011-02-16T16:01:14Z | |
| dc.date.available | 2011-02-16T16:01:14Z | |
| dc.date.issued | 2006 | |
| dc.description.abstract | Xanthones are a well-studied class of heterocyclic compounds [1] and over the years these substances have been extensively studied due to their biological properties. Both natural and synthetic derivatives have shown important anti-microbial, anti-tumour, anti-inflammatory as well as antioxidant activities [2]. Several structure/activity studies of polyphenolic compounds revealed that the presence of hydroxyl substituents in certain positions of their skeleton is of great importance for a high antioxidant activity [3]. Taking this knowledge into consideration, we report the synthesis of new polyhydroxy-2,3- diarylxanthones, starting from the 3-bromo-2-methylchromone 1. Aldol condensation of 1 with benzaldehydes leads to the formation of 3-bromo-2-styrylchromones 2 followed by Heck reaction with styrenes to give the 2,3-arylxanthones 3 [4]. The final step consists in the cleavage of protective groups to obtain the desired polyhydroxy-2,3-diarylxanthones 4 | por |
| dc.identifier.citation | Santos, Clementina M.M.; Silva, Artur; Cavaleiro, José (2006). Synthesis of Polyhydroxy-2,3-diarylxanthones with potencial antioxidant activity. In 4th Eurasian Meeting on Heterocyclic Chemistry. Tessalónica | por |
| dc.identifier.uri | http://hdl.handle.net/10198/3426 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.title | Synthesis of Polyhydroxy-2,3-diarylxanthones with potencial antioxidant activity | por |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/POCI/POCI%2FQUI%2F59284%2F2004/PT | |
| oaire.citation.conferencePlace | Tessalónica, Grécia | por |
| oaire.citation.title | 4th Eurasian Meeting on Heterocyclic Chemistry | por |
| oaire.fundingStream | POCI | |
| person.familyName | Santos | |
| person.givenName | Clementina M.M. | |
| person.identifier.ciencia-id | 9018-DB9C-C590 | |
| person.identifier.orcid | 0000-0003-4380-7990 | |
| person.identifier.scopus-author-id | 7201458663 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | por |
| rcaap.type | conferenceObject | por |
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