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|Título:||Synthesis of 6-(2’ or 4’- nitrophenyl)benzo[b]thiophenes by Palladium-catalyzed cross-coupling|
|Autor:||Ferreira, Isabel C.F.R.|
Queiroz, Maria João R.P.
|Editora:||Universidade de Aveiro|
|Citação:||Ferreira, Isabel C.F.R.; Queiroz, Maria-João R.P.; Kirsch, Gilbert (2000) – Synthesis of 6-(2’ or 4’- nitrophenyl)benzo[b]thiophenes by Palladium-catalyzed cross-coupling. In XIX th European Colloquium on Heterocyclic Chemistry. Aveiro|
|Resumo:||The palladium-catalyzed cross-coupling reactions of organoboron compounds are very useful for carbon-carbon bond formation. Compounds 1 were synthesized by a palladium-catalyzed cross-coupling of bromo or iodonitrobenzenes with boronic esters 2, which were prepared from methylated 6- bromobenzo[b]thiophenes2 by halogen-metal exchange and transmetalation. The intermediates esters 2 were not isolated but directly, after evaporation of the ether, coupled in acetone/water using palladium acetate in the presence of sodium hydrogencarbonate. Yields of isolated compounds 1 were about 40%.|
|Aparece nas colecções:||CIMO - Resumos em Proceedings Não Indexados ao WoS/Scopus|
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