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Separation of nadolol racemates by high pH reversed-phase preparative chromatography

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dc.contributor.authorArafah, Rami
dc.contributor.authorRibeiro, António E.
dc.contributor.authorRodrigues, Alírio
dc.contributor.authorPais, Luís S.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2020-01-06T14:09:17Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2020-01-06T14:09:17Z
dc.date.issued2020
dc.description.abstractThe separation of nadolol racemates under high pH reversed-phase preparative chromatography is presented for the first time. Three Waters C18 adsorbents (XBridge, Shield and XSelect) are compared for the separation of nadolol racemates using ethanol:water:diethylamine solvent mixtures. Experimental and simulation results are presented to compare the separation performances at preparative scale using both the fixed-bed and the simulated moving bed operations. The Waters XBridge C18 adsorbent and an ethanol:water:diethylamine solvent mixture are selected as a good option for the separation of nadolol racemates. The validated methodology allows the separation of a multicomponent nadolol feed mixture composed by four stereoisomers into two pure racemates (two pairs of enantiomers). This work introduces the potential of using an initial achiral separation step in the global strategy for the complete multicomponent separation of the four nadolol stereoisomers.
dc.description.sponsorshipThis work is a result of: Project “AIProcMat@N2020 - Advanced Industrial Processes and Materials for a Sustainable Northern Region of Portugal 2020”, with the reference NORTE-01-0145-FEDER-000006, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (ERDF); Associate Laboratory LSRE-LCM - UID/EQU/50020/2019 - funded by national funds through FCT/MCTES (PIDDAC). Rami S. Arafah is supported by a PhD Grant of Fundação para a Ciência e a Tecnologia (SFRH/BD/137966/2018).
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationArafah, Rami S.; Ribeiro, António E.; Rodrigues, Alírio E.; Pais, Luís S. (2020). Separation of nadolol racemates by high pH reversed-phase preparative chromatography. Separation and Purification Technology. ISSN 1383-5866. 233, p. 1-13en_EN
dc.identifier.doi10.1016/j.seppur.2019.116018en_EN
dc.identifier.issn1383-5866
dc.identifier.urihttp://hdl.handle.net/10198/19524
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.subjectMulticomponent separationen_EN
dc.subjectNadololen_EN
dc.subjectReversed-phase preparative chromatographyen_EN
dc.titleSeparation of nadolol racemates by high pH reversed-phase preparative chromatographyen_EN
dc.typejournal article
dspace.entity.typePublication
person.familyNameArafah
person.familyNameRibeiro
person.familyNamePais
person.givenNameRami
person.givenNameAntónio E.
person.givenNameLuís S.
person.identifier.ciencia-idAB16-ECBF-B886
person.identifier.ciencia-id3211-D5B0-870D
person.identifier.ciencia-id421E-0CCD-A84F
person.identifier.orcid0000-0002-7743-4988
person.identifier.orcid0000-0003-4569-7887
person.identifier.orcid0000-0002-3000-2862
person.identifier.scopus-author-id57151342900
person.identifier.scopus-author-id23390701300
person.identifier.scopus-author-id6603930478
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
relation.isAuthorOfPublication3cd4864a-8aa6-46a2-9415-767a7551ee62
relation.isAuthorOfPublication52666376-f100-4407-87ef-dc5df3613761
relation.isAuthorOfPublicationc6d25534-8487-45b1-90af-d350f4e3ac55
relation.isAuthorOfPublication.latestForDiscoveryc6d25534-8487-45b1-90af-d350f4e3ac55

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