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Supplementation of an anthocyanin-rich elderberry (Sambucus nigra L.) extract in FVB/n mice: a healthier alternative to synthetic colorants

2022Journal article Open access
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dc.contributor.authorAzevedo, Tiago
dc.contributor.authorFerreira, Tiago
dc.contributor.authorFerreira, João Miguel Mendes
dc.contributor.authorTeixeira, Filipa
dc.contributor.authorFerreira, Diana
dc.contributor.authorSilva-Reis, Rita
dc.contributor.authorNeuparth, Maria João
dc.contributor.authorPires, Maria João
dc.contributor.authorPinto, Maria de Lurdes
dc.contributor.authorCosta, Rui Miguel Gil
dc.contributor.authorBastos, Margarida M.S.M.
dc.contributor.authorMedeiros, Rui
dc.contributor.authorFelix, Luis
dc.contributor.authorVenâncio, Carlos
dc.contributor.authorDias, Maria Inês
dc.contributor.authorGaivão, Isabel
dc.contributor.authorBarros, Lillian
dc.contributor.authorOliveira, Paula A.
dc.date.accessioned2013-09-04T10:49:17Z
dc.date.available2013-09-04T10:49:17Z
dc.date.issued2022
dc.description.abstractFeatured Application Due to anthocyanins' potential as colorants, this anthocyanin-rich elderberry extract presents a healthier alternative to commercially available colorants and has the potential to be used at industry level. Sambucus nigra L., popularly known as elderberry, is renowned for its amazing therapeutic properties, as well as its uses as a food source, in nutraceuticals, and in traditional medicine. This study's aim was to investigate the effects of an elderberry extract (EE) on mice for 29 days, as well as the safety of the extract when used as a natural colorant. Twenty-four FVB/n female mice (n = 6) were randomly assigned to one of four groups: control, 12 mg/mL EE (EE12), 24 mg/mL EE (EE24), or 48 mg/mL EE (EE48). The predominant anthocyanins detected were cyanidin-3-O-sambubioside and cyanidin-3-O-glucoside. Food and drink intake were similar between groups, with the exception of EE48, who drank significantly less compared with the Control. Biochemical analysis of the liver showed that the changes observed in histological analysis had no pathological significance. The EE, at doses of 24 and 48 mg/mL, significantly reduced the oxidative DNA damage compared with the non-supplemented group. The S. nigra extract showed a favorable toxicological profile, affording it potential to be used in the food industry.
dc.identifier.citationAzevedo, Tiago; Ferreira, Tiago; Ferreira, João Miguel Mendes; Teixeira, Filipa; Ferreira, Diana; Silva-Reis, Rita; Neuparth, Maria João; Pires, Maria João; Pinto, Maria de Lurdes; Gil da Costa, Rui M.; Bastos, Margarida M.S.M.; Medeiros, Rui; Felix, Luis; Venâncio, Carlos; Dias, Maria Inês; Gaivão, Isabel; Barros, Lillian; Oliveira, Paula A.. (2022). Supplementation of an anthocyanin-rich elderberry (Sambucus nigra L.) extract in FVB/n mice: a healthier alternative to synthetic colorants. Applied Sciences. EISSN 2076-3417. 12:23, p. 1-14
dc.identifier.eissn2076-3417
dc.identifier.urihttp://hdl.handle.net/10198/8627
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherMDPIpor
dc.subjectSambucus nigra
dc.subjectIn vivo
dc.subjectOral administration
dc.subjectColorant
dc.titleSupplementation of an anthocyanin-rich elderberry (Sambucus nigra L.) extract in FVB/n mice: a healthier alternative to synthetic colorantspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleApplied Sciences
person.familyNameDias
person.familyNameBarros
person.givenNameMaria Inês
person.givenNameLillian
person.identifier469085
person.identifier.ciencia-id2A13-4BE6-C7CF
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridM-8242-2013
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id35236343600
rcaap.rightsopenAccesspor
rcaap.typearticle
relation.isAuthorOfPublication7ca8432b-e7f4-4116-a56e-9eba0d4403bd
relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublication.latestForDiscovery7ca8432b-e7f4-4116-a56e-9eba0d4403bd

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