Publication
Antifungal activity against Candida species and phenolic characterization of decoction, infusion and hydroalcoholic extract of cultivated Salvia officinalis L.
| dc.contributor.author | Martins, Natália | |
| dc.contributor.author | Barros, Lillian | |
| dc.contributor.author | Silva, Sónia | |
| dc.contributor.author | Santos-Buelga, Celestino | |
| dc.contributor.author | Henriques, Mariana | |
| dc.contributor.author | Ferreira, Isabel C.F.R. | |
| dc.date.accessioned | 2015-11-02T14:52:02Z | |
| dc.date.available | 2015-11-02T14:52:02Z | |
| dc.date.issued | 2014 | |
| dc.description.abstract | The freq uency and severity of diagnosed fungal infections is growing and, linked with thi s, it is observed an exacerbated increase of the antifungal drugs resistance. Candida albicans has been considered the main agent responsible for opportunistic pathogenic infections, but, recently, other non-C. albicans Candida species have also been considered [1]. In face to the increased number of Candida species drug resistant, it is crucial to use natural matrices to discover efficient alternative therapies to current antifungal agents. Salvia officina /is L., commonly known as sage, could be one of those natural matrices, containing a wide variety of bioactive molecules. Despite the existence of some reports on antimicrobial activity of sage, the most stud ied preparation is the essential oil, being scarce the aqueous extracts. The antifungal activity of decoction, infusion and hydroalcoholic extract of cultivated sage were evaluated, and further characterized in terms of phenolic composition (HPLC- DAD- ESIIMS). Antifungal activity was assessed against a total of 19 Candida strains of C. albicans, C. tropicalis, C. parapsilosis and C. glabrata recovered from different human biological samples. The most pronounced effect was observed against C. parapsilosis, fo llowed by C. tropicalis and C. albicans. No effect was observed against the three C. glabrata stra ins. In general, decoction presented the most pronounced effect, followed by infusion and hydroalcoholic extract, varying directly according with the extract concentration. Decoction also showed the highest concentration in phenolic compounds, followed by hydroalcoholic extract and infusions. Rosmarinic acid and luteolin 7-0-glucuronide were the main phenolic compounds. Thus, the use of sage decoction, incorporated on daily food dietary, or even as complement to an antifungal therapy, could provide considerable benefits, not only by internal but also external use, without the common side effects reported for essential oil. | pt_PT |
| dc.identifier.citation | Martins, Natália; Barros, Lillian; Silva, Sónia; Santos-Buelga, Celestino; Henriques, Mariana; Ferreira, Isabel C.F.R. (2014). Antifungal activity against Candida species and phenolic characterization of decoction, infusion and hydroalcoholic extract of cultivated Salvia officinalis L. In 62th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research - GA2014. Guimarães | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10198/12242 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Antifungal activity | pt_PT |
| dc.subject | Candida species | pt_PT |
| dc.subject | Salvia officina/is L. | pt_PT |
| dc.subject | Phenolic compounds | pt_PT |
| dc.title | Antifungal activity against Candida species and phenolic characterization of decoction, infusion and hydroalcoholic extract of cultivated Salvia officinalis L. | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.title | 62th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research- GA2014 | pt_PT |
| person.familyName | Barros | |
| person.familyName | Ferreira | |
| person.givenName | Lillian | |
| person.givenName | Isabel C.F.R. | |
| person.identifier | 469085 | |
| person.identifier | 144781 | |
| person.identifier.ciencia-id | 9616-35CB-D001 | |
| person.identifier.ciencia-id | 9418-CF95-9919 | |
| person.identifier.orcid | 0000-0002-9050-5189 | |
| person.identifier.orcid | 0000-0003-4910-4882 | |
| person.identifier.rid | J-3600-2013 | |
| person.identifier.rid | E-8500-2013 | |
| person.identifier.scopus-author-id | 35236343600 | |
| person.identifier.scopus-author-id | 36868826600 | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |
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