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HPLC-DAD-ESI-MS/MS screening of phytochemical compounds and the bioactive properties of different plant parts of: Zizyphus lotus (L.) Desf.

2019Journal article Open access
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dc.contributor.authorRached, Wahiba
dc.contributor.authorBarros, Lillian
dc.contributor.authorZiani, Borhane E.C.
dc.contributor.authorBennaceur, Malika
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorHeleno, Sandrina A.
dc.contributor.authorAlves, Maria José
dc.contributor.authorMarouf, Abderrazak
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2020-01-06T14:10:18Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2020-01-06T14:10:18Z
dc.date.issued2019
dc.description.abstractZizyphus lotus L. (Desf.) has been widely used as a homemade ingredient to treat numerous diseases in Algerian folk medicine. In this context, decoction, infusion and hydroethanolic extracts were prepared from the branches, leaves, roots, and stem barks. The extracts were characterized regarding their phytochemical composition by HPLC-DAD-ESI/MSn and were assessed for in vitro bioactivity (cytotoxicity, anti-inflammatory activity, and antibacterial activity). A total of 29 compounds (flavonoid derivatives and secoiridoids) were identified in Z. lotus, 15 being detected in leaves, 10 in branches, 5 in roots and 7 in stem barks. The highest contents of these compounds, especially secoiridoids, were detected in branches followed by leaves, oleuropein being the main compound detected in leaves and oleoside in branches. The aqueous preparations of the leaves and root barks revealed the highest cytotoxicity and anti-inflammatory potential. On the other hand, as for the antibacterial activity, the hydroethanolic extract of the branches showed the highest potential, especially against the MSSA strain. Hence, the chemical diversity found in Z. lotus makes it a source of bioactive ingredients that can be applied in the formulations of different ingredients in the food and pharmaceutical industries.
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) and FEDER under Program PT2020 for financial support to CIMO (UID/AGR/00690/2019); to the national funding by FCT, P. I., through the institutional scientific employment program-contract for L. Barros and R. Calhelha and through the individual scientific employment program-contract for S. A. Heleno; to the University of Mostaganem and MESRS of Algeria for the financial support that allowed to achieve this work; and also to the Interreg España-Portugal for financial support through the project 0377_Iberphenol_6_E.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationRached, Wahiba; Barros, Lillian; Ziani, Borhane E.C.; Bennaceur, Malika; Calhelha, Ricardo C.; Heleno, Sandrina A.; Alves, Maria José; Marouf, Abderrazak; Ferreira, Isabel C.F.R. (2019). HPLC-DAD-ESI-MS/MS screening of phytochemical compounds and the bioactive properties of different plant parts of: Zizyphus lotus (L.) Desf.. Food and Function. ISSN 2042-6496. 10, p. 5898-5909en_EN
dc.identifier.doi10.1039/c9fo01423cen_EN
dc.identifier.issn2042-6496
dc.identifier.urihttp://hdl.handle.net/10198/20267
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relation0377_Iberphenol_6_E
dc.titleHPLC-DAD-ESI-MS/MS screening of phytochemical compounds and the bioactive properties of different plant parts of: Zizyphus lotus (L.) Desf.en_EN
dc.typejournal article
dspace.entity.typePublication
person.familyNameBarros
person.familyNameCalhelha
person.familyNameHeleno
person.familyNameAlves
person.familyNameFerreira
person.givenNameLillian
person.givenNameRicardo C.
person.givenNameSandrina A.
person.givenNameMaria José
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id8B18-3095-6FC9
person.identifier.ciencia-idD618-B3A9-D312
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0001-7224-1098
person.identifier.orcid0000-0001-8506-4393
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridJ-2172-2014
person.identifier.ridL-5951-2014
person.identifier.ridM-6624-2016
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id30067731800
person.identifier.scopus-author-id16400584800
person.identifier.scopus-author-id36868826600
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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