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Toxicity and safety of nutraceuticals

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dc.contributor.authorBarciela, Paula
dc.contributor.authorPerez-Vazquez, Ana
dc.contributor.authorMansour, Sepidar
dc.contributor.authorDonn, Pauline
dc.contributor.authorGarcia-Perez, P.
dc.contributor.authorCarpena, Maria
dc.contributor.authorFraga-Corral, Maria
dc.contributor.authorSimal-Gandara, Jesus
dc.contributor.authorPrieto Lage, Miguel A.
dc.date.accessioned2025-01-30T11:46:51Z
dc.date.available2025-01-30T11:46:51Z
dc.date.issued2024
dc.description.abstractCurrently, consumers are more conscious about the importance of having a good diet and lifestyle; so the demand for products with potential health benefits has increased. Nutraceuticals can be classified according to different criteria. Based on their chemical structure, they can be divided into phenolic compounds, fatty acids and structural lipids, carbohydrates and amino-acids derivatives, minerals, and terpenoids derivatives. All these compounds are linked to different health benefits, such as antioxidant, anticancer and anti-inflammatory activity, prevention of neurodegenerative and cardiovascular diseases, or health bones maintenance. However, the potential positive impact of these compounds when incorporated in the human body is limited because of their bioavailability, which is mainly affected because of the hydrophobic properties of these compounds. In this way, different delivery systems were developed as suitable pathways for the bioavailability improvement of nutraceuticals. The most successful delivery systems to incorporate nutraceuticals include micro and nanoemulsions, micelles, nanoparticles, hydrogels, and solid-lipid nanoparticles. They achieved several improvements such as higher bioavailability, bioactivity maintenance, shelf-life improvement, or incorporation of the nutraceutical in a target system/organ. In this way, and considering the increasing demand for these products, the development of regulation is needed so that consumers' safety is assured, although any country has developed it yet. Thus, considering the increasing demand for these compounds, the aim of this study was to compile the available current data of nutraceuticals and also their safety concerns. © 2024 Walter de Gruyter GmbH, Berlin/Boston. All rights reserved.pt_PT
dc.description.sponsorshipThe research leading to these results was supported by MICINN supporting the Ramón y Cajal grant for M.A. Prieto (RYC-2017-22,891); by Xunta de Galicia for supporting the program EXCELENCIA-ED431F 2020/12, the post-doctoral grant of M. Fraga-Corral (ED481B-2019/096), and the pre-doctoral grant of M. Carpena (ED481A 2021/313). Authors are grateful to Ibero-American Program on Science and Technology (CYTED - AQUA-CIBUS, P317RT0003), and to the Bio Based Industries Joint Undertaking (JU) under grant agreement No 888003 UPHEALTH Project (H2020-BBI-JTI-2019). The UJ receives support from the European Union's Horizon 2020 research and innovation program and the Bio Based Industries Consortium. The project SYSTEMIC Knowledge hub on Nutrition and Food Security, has received funding from national research funding parties ni Belgium (FWO), France (INRA), Germany (BLE), Italy (MIPAAF), Latvia (IZM), Norway (RCN), Portugal (FCT), and Spain (AEL) in a joint action of JPI HDHL, JPI- OCEANS and FACCE-JPI launched in 2019 under the ERA-NET ERA-HDHL (n° 696295).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBarciela, Paula; Perez-Vazquez, Ana; Mansour, Sepidar; Donn, Pauline; Garcia-Perez, P.; Carpena, Maria; Fraga-Corral, Maria; Simal-Gandara, Jesus; Prieto Lage, Miguel A. (2024). Toxicity and safety of nutraceuticals. In Nutraceuticals: A Holistic Approach to Disease Prevention. Berlin: Walter de Gruyter, p. 345-364. ISBN 978-311131760-1pt_PT
dc.identifier.doi10.1515/9783111317601-016pt_PT
dc.identifier.isbn978-311131760-1
dc.identifier.urihttp://hdl.handle.net/10198/31102
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWalter de Gruyterpt_PT
dc.relationSustainable and cost-effective production process for the upcycling of olive, grape and nut by-products into 4 natural and healthy ingredients for nutraceutical and cosmetic applications
dc.relationERA-NET Biomarkers for Nutrition and Health implementing the JPI HDHL objectives
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectFatty acidspt_PT
dc.subjectLipidspt_PT
dc.subjectNanoparticlespt_PT
dc.subjectNeurodegenerative diseasespt_PT
dc.titleToxicity and safety of nutraceuticalspt_PT
dc.typebook part
dspace.entity.typePublication
oaire.awardTitleSustainable and cost-effective production process for the upcycling of olive, grape and nut by-products into 4 natural and healthy ingredients for nutraceutical and cosmetic applications
oaire.awardTitleERA-NET Biomarkers for Nutrition and Health implementing the JPI HDHL objectives
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/888003/EU
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/696295/EU
oaire.citation.endPage364pt_PT
oaire.citation.startPage345pt_PT
oaire.citation.titleNutraceuticals: A Holistic Approach to Disease Preventionpt_PT
oaire.fundingStreamH2020
oaire.fundingStreamH2020
person.familyNameFraga-Corral
person.familyNamePrieto Lage
person.givenNameMaria
person.givenNameMiguel A.
person.identifier1054547
person.identifier107688
person.identifier.ciencia-id1616-98AD-4546
person.identifier.ciencia-id221E-1E00-AB74
person.identifier.orcid0000-0002-5663-9239
person.identifier.orcid0000-0002-3513-0054
person.identifier.ridG-7335-2017
person.identifier.ridG-4516-2011
person.identifier.scopus-author-id56346469200
person.identifier.scopus-author-id35937495700
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
project.funder.nameEuropean Commission
rcaap.rightsrestrictedAccesspt_PT
rcaap.typebookPartpt_PT
relation.isAuthorOfPublication446f0a90-be7c-4111-9949-42475fda0e6a
relation.isAuthorOfPublication13260615-fd28-4b8b-9dd4-8a8466007579
relation.isAuthorOfPublication.latestForDiscovery13260615-fd28-4b8b-9dd4-8a8466007579
relation.isProjectOfPublication9980c0d6-0317-49a0-a44d-b8aedf2294a5
relation.isProjectOfPublication160ee2e3-b63a-4185-ac5d-5deb7281fef2
relation.isProjectOfPublication.latestForDiscovery160ee2e3-b63a-4185-ac5d-5deb7281fef2

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