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Biological activity of 6,7-Dehydroxyroyleanone and derivatives obtained from Plectranthus aliciae (Codd) A.J.Paton

2024Journal article Open access
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dc.contributor.authorFilipe, Márcia Santos
dc.contributor.authorDomínguez-Martín, Eva M.
dc.contributor.authorPires, Tânia C.S.P.
dc.contributor.authorFinimundy, Tiane C.
dc.contributor.authorMelgar Castañeda, Bruno
dc.contributor.authorMandim, Filipa
dc.contributor.authorIsca, Vera M. S.
dc.contributor.authorPereira, Raquel
dc.contributor.authorTeixidó-Trujillo, Silvia
dc.contributor.authorCapote, Natalia A.
dc.contributor.authorNikolić, Milan
dc.contributor.authorFilipović, Nenad
dc.contributor.authorDíaz-Lanza, Ana M.
dc.contributor.authorFigueiredo, Ana Cristina
dc.contributor.authorBarros, Lillian
dc.contributor.authorRijo, Patrícia
dc.date.accessioned2024-05-02T10:13:25Z
dc.date.available2024-05-02T10:13:25Z
dc.date.issued2024
dc.description.abstractThe Plectranthus genus (Lamiaceae) is known to be rich in abietane diterpenes. The bioactive 6,7-dehydroxyroyleanone (DHR, 1) was previously isolated from Plectranthus madagascariensis var. madagascariensis and var. aliciae. This study aimed to explore the occurrence of DHR, 1, in P. aliciae and the potential bioactivities of new semisynthetic derivatives from DHR, 1. Several extraction methods were evaluated, and the hydrodistillation, using a Clevenger apparatus, afforded the highest yield (77.8 mg/g of 1 in the essential oil). Three new acyl derivatives (2-4) were successfully prepared from 1 (yields of 86-95%). Compounds 1-4 showed antioxidant activity, antibacterial effects, potent cytotoxic activity against several cell lines, and enhanced anti-inflammatory activity that surpassed dexamethasone (positive control). These findings encourage further exploration of derivatives 2-4 for potential mechanisms of antitumoral, antioxidant, and anti-inflammatory capabilities, studying both safety and efficacy.pt_PT
dc.description.sponsorshipThis work was supported by the funding received by Fundação paraaCien̂ciaeTecnologia(FCT,Portugal)(projects DOI 10.54499/UIDP/04567/2020 and DOI 10.54499/UIDB/04567/2020 attributed to CBIOS, CIMO (UIDB/00690/2020 and UIDP/00690/2020), CESAM (UIDP/50017/2020, UIDB/50017/2020, LA/P/0094/2020), and SusTEC (LA/P/0007/2020) and a Ph.D. grant for F.M. (SFRH/BD/ 146614/2019). National funding was provided by FCT, P.I., through the institutional scientific employment program contracts (L.B.). E.M.D.-M. gratefully acknowledges being the recipient of a FPU-UAH 2019 contract and for the grant “Ayudas a la Movilidad del Personal Investigador en Formación 2022” from the University of Alcalá de Henares (UAH). The authors thank the laboratory CIMO-ESTIG for permission to use the balance ABT-100 ESM Kern (Balingen, Germany) and Escola Superior Agrária laboratory for the use of the mill IKA-WERKE M20.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFilipe, Márcia S.; Domínguez-Martín, Eva M.; Pires, Tânia C.S.P.; Finimundy, Tiane C.; Melgar, Bruno; Mandim, Filipa; Isca, Vera M.S.; Pereira, Raquel; Teixidó-Trujillo, Silvia; Capote, Natalia A.; Nikolić, Milan; Filipović, Nenad; Díaz-Lanza, Ana M.; Figueiredo, Ana Cristina; Barros, Lillian; Rijo, Patrícia (2024). Biological activity of 6,7-Dehydroxyroyleanone and derivatives obtained from Plectranthus aliciae (Codd) A.J.Paton. ACS Omega. EISSN 2470-1343. 9:16, p. 18113-18118pt_PT
dc.identifier.doi10.1021/acsomega.3c10071pt_PT
dc.identifier.eissn2470-1343
dc.identifier.urihttp://hdl.handle.net/10198/29706
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherACSpt_PT
dc.relationResearch Center for Biosciences & Health Technologies
dc.relationResearch Center for Biosciences & Health Technologies
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationCentre for Environmental and Marine Studies
dc.relationCentre for Environmental and Marine Studies
dc.relationCentre for Environmental and Marine Studies
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.relationIntegrated strategies for the development of a novel functional beverage with sustainable production systems
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPlectranthuspt_PT
dc.subjectEssential oilpt_PT
dc.titleBiological activity of 6,7-Dehydroxyroyleanone and derivatives obtained from Plectranthus aliciae (Codd) A.J.Patonpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleResearch Center for Biosciences & Health Technologies
oaire.awardTitleResearch Center for Biosciences & Health Technologies
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardTitleIntegrated strategies for the development of a novel functional beverage with sustainable production systems
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04567%2F2020/PT
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oaire.citation.endPage18118pt_PT
oaire.citation.issue16pt_PT
oaire.citation.startPage18113pt_PT
oaire.citation.titleACS Omegapt_PT
oaire.citation.volume9pt_PT
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project.funder.identifierhttp://doi.org/10.13039/501100001871
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rcaap.typearticlept_PT
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