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Protective properties of the edible halophyte Carpobrotus edulis (L.) N.E.Br. towards neoformed food contaminants-related oxidative stress and genotoxicity

2024Journal article Restricted access
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dc.contributor.authorOliveira, Daniela
dc.contributor.authorHayrapetyan, Ruzanna
dc.contributor.authorDias, Maria Inês
dc.contributor.authorBarros, Lillian
dc.contributor.authorSéverin, Isabelle
dc.contributor.authorCustódio, Luísa
dc.contributor.authorChagnon, Marie-Christine
dc.contributor.authorOliveira, Rui P.
dc.date.accessioned2024-07-31T10:53:05Z
dc.date.available2024-07-31T10:53:05Z
dc.date.issued2024
dc.description.abstractCarpobrotus edulis (L.) N.E.Br. is an edible halophyte native to South Africa, where it has been traditionally consumed as food, revealing its nutritional value, and used in the treatment of human diseases probably due to the accumulation of bioactive compounds such as polyphenols. These compounds have potential to display valuable biological activities that could bring several benefits to the human being, including the mitigation of toxicity induced by food contaminants. Therefore, this study investigated biological activities with health-promoting potential of a C. edulis ethanol extract (CEE), such as antioxidant, antigenotoxic, and antimutagenic. CEE was shown by LC-DAD-ESI/MSn to be composed of 16 polyphenols. The extract exhibited antioxidant properties by protecting Saccharomyces cerevisiae viability and improving the redox state of HepG2 cells under oxidative stress. Antigenotoxicity of CEE against H2O2-induced oxidative damage was detected in HepG2 and Caco-2 cells by comet assay and subsequently observed in the dominant deletion assay in S. cerevisiae. Antigenotoxicity and antimutagenicity of CEE towards the neoformed contaminant benzo[a]pyrene was found in HepG2 and Caco-2 cells by comet assay and in Salmonella typhimurium using the Ames test, respectively. The disclosed antigenotoxic and antimutagenic properties of C. edulis further advance its potential for application in food and nutraceutical industries for health benefits.pt_PT
dc.description.sponsorshipD. Oliveira acknowledges the financial support provided by national funds through FCT \u2013 Portuguese Foundation for Science and Technology (PD/BD/135329/2017; COVID/BD/152478/2022), under the PhD AgriChains (PD/00122/2012) and from the European Social Funds and the Regional Operational Programme Norte 2020. This study was also supported by the research units CITAB (UIDB/04033/2020) and CBMA (UIDB/04050/2020). L. Cust\u00F3dio acknowledges FCT for the UIDB/04326/2020 and PTDC/BAA-AGR/1391/2020 projects, and Scientific Employment Stimulus (CEECIND/00425/2017). This work was supported by national funds through FCT/MCTES (PIDDAC): CIMO, UIDB/00690/2020 (DOI: 10.54499/UIDB/00690/2020) and UIDP/00690/2020 (DOI: 10.54499/UIDP/00690/2020); and SusTEC, LA/P/0007/2020 (DOI: 10.54499/LA/P/0007/2020); National funding by FCT, P.I., through the individual scientific employment program-contract for M.I. Dias and L. Barros contracts.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationOliveira, Daniela; Hayrapetyan, Ruzanna; Dias, Maria Inês; Barros, Lillian; Séverin, Isabelle; Custódio, Luísa; Chagnon, Marie-Christine; Oliveira, Rui P. (2024). Protective properties of the edible halophyte Carpobrotus edulis (L.) N.E.Br. towards neoformed food contaminants-related oxidative stress and genotoxicity. Food Bioscience. ISSN 2212-4292. 61, p. 1-12pt_PT
dc.identifier.doi10.1016/j.fbio.2024.104447pt_PT
dc.identifier.issn2212-4292
dc.identifier.urihttp://hdl.handle.net/10198/30134
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationValorisation of halophyte plants present in Portuguese territory through the investigation of their protective effects against food toxicants - Study of bioactivities of plant-based products to attenuate the effects of food toxicants
dc.relationCentre for the Research and Technology of Agro-Environmental and Biological Sciences
dc.relationCENTRE OF MOLECULAR AND ENVIRONMENTAL BIOLOGY
dc.relationAlgarve Centre for Marine Sciences
dc.relationNot Available
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectAntigenotoxicpt_PT
dc.subjectAntimutagenicpt_PT
dc.subjectBenzo[a]pyrenept_PT
dc.subjectCarpobrotus edulis (L.) N.E.Brpt_PT
dc.subjectHalophytept_PT
dc.subjectSour figpt_PT
dc.titleProtective properties of the edible halophyte Carpobrotus edulis (L.) N.E.Br. towards neoformed food contaminants-related oxidative stress and genotoxicitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleValorisation of halophyte plants present in Portuguese territory through the investigation of their protective effects against food toxicants - Study of bioactivities of plant-based products to attenuate the effects of food toxicants
oaire.awardTitleCentre for the Research and Technology of Agro-Environmental and Biological Sciences
oaire.awardTitleCENTRE OF MOLECULAR AND ENVIRONMENTAL BIOLOGY
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleNot Available
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//COVID%2FBD%2F152478%2F2022/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F00425%2F2017%2FCP1391%2FCT0001/PT
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oaire.citation.endPage12pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleFood Biosciencept_PT
oaire.citation.volume61pt_PT
oaire.fundingStreamPOR_NORTE
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oaire.fundingStreamConcurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Científicos - 2020
oaire.fundingStreamCEEC IND 2017
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person.familyNameDias
person.familyNameBarros
person.givenNameMaria Inês
person.givenNameLillian
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person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id35236343600
project.funder.identifierhttp://doi.org/10.13039/501100001871
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