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Phenolic acids, cinnamic acid, and ergosterol as cosmeceutical ingredients: Stabilization by microencapsulation to ensure sustained bioactivity

2019Artigo científico Acesso aberto
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dc.contributor.authorTaofiq, Oludemi
dc.contributor.authorHeleno, Sandrina A.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorFernandes, Isabel P.
dc.contributor.authorAlves, Maria José
dc.contributor.authorBarros, Lillian
dc.contributor.authorGonzález-Paramás, Ana María
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorBarreiro, M.F.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2020-01-06T14:10:49Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2020-01-06T14:10:49Z
dc.date.issued2019
dc.description.abstractThe global cosmetic industry is constantly searching for new ingredients with multifunctional properties. In this context, phenolic compounds (p-hydroxybenzoic, p-coumaric, and protocatechuic acids), cinnamic acid and ergosterol were evaluated for their anti-inflammatory, anti-tyrosinase and antimicrobial activities, and thereafter microencapsulated by the atomization/coagulation technique. After characterization (morphology, particle size distribution and encapsulation efficiency), the microencapsulated compounds were incorporated into a semi-solid base cream and their performance evaluated comparatively with the use of the free forms. The cosmeceutical formulations were checked regarding the presence of the bioactive compounds by HPLC-DAD, and for their physicochemical properties (colour and pH). The obtained results demonstrated the anti-tyrosinase, anti-inflammatory and antimicrobial activities of the individual compounds that, after incorporation, have shown a decreasing pattern along time. On the contrary, the formulations incorporating the microencapsulated bioactive compounds gave rise to a gradual release, ensuring bioactivity maintenance. These results underline the advantage of using microencapsulation to preserve and ensure the controlled release of bioactive species in cosmeceutical formulations.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationTaofiq, Oludemi; Heleno, Sandrina A.; Calhelha, Ricardo C.; Fernandes, Isabel P.; Alves, Maria José; Barros, Lillian; González-Paramás, Ana M.; Ferreira, Isabel C.F.R.; Barreiro, Maria F. (2019). Phenolic acids, cinnamic acid, and ergosterol as cosmeceutical ingredients: Stabilization by microencapsulation to ensure sustained bioactivity. Microchemical Journal. ISSN 0026-265X. 147, p. 469-477en_EN
dc.identifier.doi10.1016/j.microc.2019.03.059en_EN
dc.identifier.issn0026-265X
dc.identifier.urihttp://hdl.handle.net/10198/20293
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relation0377_Iberphenol_6_E
dc.subjectBioactive compoundsen_EN
dc.subjectBioactive propertiesen_EN
dc.subjectControlled releaseen_EN
dc.subjectCosmeceuticalsen_EN
dc.subjectMicroencapsulationen_EN
dc.titlePhenolic acids, cinnamic acid, and ergosterol as cosmeceutical ingredients: Stabilization by microencapsulation to ensure sustained bioactivityen_EN
dc.typejournal article
dspace.entity.typePublication
person.familyNameHeleno
person.familyNameCalhelha
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person.familyNameAlves
person.familyNameBarros
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person.givenNameSandrina A.
person.givenNameRicardo C.
person.givenNameIsabel P.
person.givenNameMaria José
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.givenNameFilomena
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rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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