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Advisor(s)
Abstract(s)
This work describes a systematic approach to rapid development of simulated moving bed (SMB) chiral chromatographic separations. The presented methodology involves several pulse experiments using a single-column to screen the best mobile phase composition using a Chiralpak AD stationary phase and equilibrium adsorption data used to specify the initial flow rates of the SMB operation.
Description
Keywords
Nadolol Chiral separation Mobile phase composition Simulated moving red
Citation
Ribeiro, António E.; Pais, L. S.; Rodrigues, Alírio E. (2012). Chiral separation of nadolol stereoisomers by liquid chromatography : screening of mobile phase composition and SMB separation. In ANQUE's International Congress of Chemical Engineering (ANQUE-ICCE 2012. Sevilla, Spain