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Exploring the Bioactive Properties of Hydroethanolic Cork Extracts of Quercus cerris and Quercus suber

2024Journal article Open access
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dc.contributor.authorSen, Umut
dc.contributor.authorAlmeida, Daiana
dc.contributor.authorSilveira, Tayse F. F. da
dc.contributor.authorPires, Tânia C.S.P.
dc.contributor.authorAñibarro-Ortega, Mikel
dc.contributor.authorMandim, Filipa
dc.contributor.authorBarros, Lillian
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorPereira, Helena
dc.contributor.authorFernandes, Ângela
dc.date.accessioned2024-10-16T08:29:48Z
dc.date.available2024-10-16T08:29:48Z
dc.date.issued2024
dc.description.abstractThe bioactive properties of underutilized corks such as Quercus cerris cork and planted Quercus suber cork in the Eastern Mediterranean are not well-known but are crucial in developing lignocellulosic biorefineries. To assess their biological potential, hydroethanolic cork extracts of Quercus cerris and Quercus suber were analyzed for phenolic composition, antioxidant, antiproliferative, antimicrobial activities, and hepatoxicity, as well as NO-production inhibition. Here, we show that a mild hydroethanolic extraction of Q. cerris and Q. suber corks yielded 3% phenolic extracts. The phenolic composition was similar in both cork extracts, with phenolic acids and ellagitannins as the primary compounds. The bioactivity of hydroethanolic cork extracts from Q. cerris surpassed that of Q. suber and showed effectiveness against all cancer cell lines tested. This first comprehensive study on the bioactivities of different corks involves detailed characterizations of phenolic compounds of cork extracts using UPLC-DAD-ESI/MSn, evaluations of the antioxidant properties with TBARS and OxHLIA methods, evaluation of antiproliferative activity against gastric (AGS), lung (NCI-H460), colon (CaCo2), and breast cancer (MCF7) cell lines, as well as evaluations of hepatotoxicity and NO-production inhibition. The findings from this study will help bolster the potential of using underutilized cork-rich barks as a valuable resource in bark-based biorefineries.pt_PT
dc.description.sponsorshipA.U. Sen acknowledges support from FCT through a research contract (DL 57/2016). The authors are grateful to FCT for financial support through national funds to CIMO (UIDB/00690/2020 (DOI: 10.54499/UIDB/00690/2020) and UIDP/00690/2020 (DOI: 10.54499/UIDP/00690/2020)), SusTEC (LA/P/0007/2020 (DOI: 10.54499/LA/P/0007/2020)) and CEF (UIDB/00239/2020 and UIDP/00239/2020 (DOI: 10.54499/UIDB/00239/2020 and DOI: 10.54499/UIDP/00239/2020). Contracts for L. Barros and Â. Fernandes (DOI: 10.54499/CEECINST/00016/2018/CP1505/CT0008) were funded by FCT, through the institutional scientific employment program.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSen, Umut; Almeida, Daiana; da Silveira, Tayse F. F.; Pires, Tânia S. P.; Añibarro-Ortega, Mikel; Mandim, Filipa; Barros, Lillian; Ferreira, Isabel C. F. R.; Pereira, Helena; Fernandes, Ângela (2024). Exploring the Bioactive Properties of Hydroethanolic Cork Extracts of Quercus cerris and Quercus suber. Processes. ISSN 2227-9717. 12:8, p. 1-11pt_PT
dc.identifier.doi10.3390/pr12081579pt_PT
dc.identifier.issn2227-9717
dc.identifier.urihttp://hdl.handle.net/10198/30421
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.relationForest Research Centre
dc.relationForest Research Centre
dc.relationNot Available
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectQuercuspt_PT
dc.subjectAntioxidantpt_PT
dc.subjectAntiproliferative activitypt_PT
dc.subjectAntimicrobial activitypt_PT
dc.titleExploring the Bioactive Properties of Hydroethanolic Cork Extracts of Quercus cerris and Quercus suberpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
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oaire.awardTitleForest Research Centre
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00239%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST%2F00016%2F2018%2FCP1505%2FCT0008/PT
oaire.citation.endPage11pt_PT
oaire.citation.issue8pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleProcessespt_PT
oaire.citation.volume12pt_PT
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